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An inhibitory acetylcholine receptor gates context dependent mechanosensory processing in C. elegans .
bioRxiv 2024 March 28
An animal's current behavior influences its response to sensory stimuli, but the molecular and circuit-level mechanisms of this context-dependent decision-making is not well understood. In the nematode C. elegans , inhibitory feedback from turning associated neurons alter downstream mechanosensory processing to gate the animal's response to stimuli depending on whether the animal is turning or moving forward [1-3]. Until now, the specific neurons and receptors that mediate this inhibitory feedback were not known. We use genetic manipulations, single-cell rescue experiments and high-throughput closed-loop optogenetic perturbations during behavior to reveal the specific neuron and receptor responsible for receiving inhibition and altering sensorimotor processing. An inhibitory acetylcholine gated chloride channel comprised of lgc-47 and acc-1 expressed in neuron RIM receives inhibitory signals from turning neurons and performs the gating that disrupts the worm's mechanosensory evoked reversal response.
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