Redoxisome update:TRX and TXNIP/TBP2-dependent Regulation of NLRP-1/NLRP-3 Inflammasome.

Recent studies by Ball et al (Ball et al., 2022) and Zhang et al (Zhang et al., 2023) have provided evidence for the direct binding of thioredoxin1 (TRX1) to a component of inflammasome complex NLRP-1. This interaction suggests a potential role for TRX1 in the regulation of the NLR family pyrin domain containing 1 (NLRP-1) inflammasome. Furthermore, the NLRP-3 inflammasome is known to bind TRX1 and its inhibitor, thioredoxin-binding protein-2/thioredoxin-interacting protein/vitamin D3 upregulated protein-1 (TBP2/TXNP1/VDUP-1). This binding forms a redox-sensitive complex, termed the "Redoxisome", as described previously. However, the specific functions of NLRP-1 within the redoxisome complex remain undefined.