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A novel case of Horner syndrome as the presenting sign of craniosynostosis.
Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus 2024 Februrary 17
Craniosynostosis, the premature fusion of cranial sutures, can lead to distortion of skull shape and neurological dysfunction. We present a novel case of Horner syndrome as the presenting sign of craniosynostosis associated with elevated intracranial pressure. A 10-year-old boy presenting for strabismus follow-up was noted to have new-onset anisocoria, greater in the dark, and mild right upper eyelid ptosis. Apraclonidine testing was concerning for Horner syndrome. Neuroimaging demonstrated previously undiagnosed sagittal craniosynostosis with tortuous optic nerves and large cerebrospinal fluid spaces around both optic nerves. The patient was referred to neurosurgery and underwent a lumbar puncture with an opening pressure of 44 cm H2 O. He underwent surgical cranial expansion. By six months postoperatively, his anisocoria had resolved.
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