A case of tachycardia-induced acute kidney injury by renal hypouricemia.

UNLABELLED: Idiopathic renal hypouricemia is an autosomal recessive hereditary disease, characterized by hypouricemia and high renal fractional excretion of uric acid, and can be complicated by acute kidney injury after anaerobic exercise. However, no report has suggested tachycardia-induced acute kidney injury complicated with renal hypouricemia. We herein report the case of a 12-year-old female with tachycardia-induced acute kidney injury complicated with renal hypouricemia. It is an important issue that the tachycardias and acute kidney injury due to renal hypouricemia can be deteriorating factors for each other through the reactive oxygen species.

LEARNING OBJECTIVE: Renal hypouricemia is rare, with a frequency of 0.2-0.4 %, but is often overlooked and can produce acute kidney injury after exercise. Tachyarrhythmia can be an inducer of acute kidney injury in patients with renal hypouricemia.