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Synthesis of [ 3 H]Org24598 using in-house prepared [ 3 H]MeI.
Journal of Labelled Compounds & Radiopharmaceuticals 2024 January 15
The synthesis of tritium-labelled glycine transporter 1 inhibitor Org24598 is reported. Because of the instability of the Org24598 skeleton under hydrogenation conditions, a synthetic approach using an in-house prepared tritium-labelled alkylating agent ([3 H]MeI, SA = 26.2 Ci/mmol) was employed. Alternative methods of labelling are discussed.
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