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Anti-G with Concomitant Anti-D and Anti-C in a Pre-natal Patient, in India: Multi-disciplinary Approach to Diagnosis and Management.
Journal of Obstetrics and Gynaecology of India 2023 December
'G' antigen belongs to the Rh family and it was first described by Allen and Tippet in 1958. Various anti-D, anti-C, and anti-G antibody combinations can be found in patients. Ruling out the presence of anti-D is important for administering RhIg prophylaxis in RhD-negative pregnant women to prevent hemolytic disease of fetus and newborn (HDFN). RhIg prophylaxis is not indicated in the presence of an anti-D antibody. Time-to-time monitoring and follow-up of cases of RhD-negative pregnant women with a multi-disciplinary approach including an obstetrician, neonatologist, and transfusion medicine specialist helps diagnose, manage, and monitor HDFN in such cases. This case report emphasizes the need for proper antibody identification (anti-G) and managing HDFN (with intrauterine transfusions and exchange transfusion) during the perinatal period.
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