We have located links that may give you full text access.
Ketone-derived 2,3-dihydroquinazolinones in N -heteroarene C-H alkylation via C-C bond scission under oxidative metal catalysis.
Chemical Communications : Chem Comm 2022 November 11
A silver-catalysed oxidative sp2 C-H alkylation of N -heteroarenes with ketone-derived 2,3-dihydroquinazolinones at room temperature is developed. The combination of a metal catalyst and perdisulfate oxidant promotes the rarely explored thermal activation of pre-aromatic 2,3-dihydroquinazolinone to generate an alkyl radical, supported by mechanistic studies. In addition to the broad scope, good functionality tolerance, late stage functionalization of APIs, and synthesis of a novel Papaverine analogue, the utilization of an N -heteroarene C-H bond and ketone as a non-trivial alkyl radical source represents the salient feature of this method.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app