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Dopamine D 2 and Adenosine A 2A Receptors Interaction on Ca 2+ Current Modulation in a Rodent Model of Parkinsonism.

Ernesto Alberto Rendón-Ochoa, Montserrat Padilla-Orozco, Vladimir Melesio Calderon, Victor Hugo Avilés-Rosas, Omar Hernández-González, Teresa Hernández-Flores, María Belén Perez-Ramirez, Marcela Palomero-Rivero, Elvira Galarraga, José Bargas
ASN Neuro 2022 January
SUMMARY STATEMENT: A2A receptor required previous D2 receptor activation to modulate Ca2+ currents. Istradefylline decreases pramipexole modulation on Ca2+ currents. Istradefylline reduces A2A  + neurons activity in striatial microcircuit, but pramipexole failed to further reduce neuronal activity.

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