The Current Status of Cell-Based Therapies for Primary Knee Osteoarthritis

Rushabh M Vakharia, Martin W Roche, Jose Carlos Alcerro, Carlos Jesus Lavernia
Orthopedic Clinics of North America 2019, 50 (4): 415-423
There is a growing interest in cell therapy for knee osteoarthritis. This study systematically reviews the current status of cell-based therapies. The authors review treatment modalities, clinical outcomes, and the economics of cell therapy. Inclusion criteria were articles containing cellular therapy, platelet-rich plasma, and knee osteoarthritis in the title. Letters, editorial material, abstracts not published, and manuscripts with incomplete data were excluded. Forty-two articles met these inclusion criteria and were critically reviewed. Cell-based therapy holds promise as a means of restoring deficient local cartilage cell populations. There is no evidence-based information for the use of cell-based therapies in knee osteoarthritis.


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