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Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BACT/ALERT® or BACTEC™ Resin-Containing Media in Simulated Adult Blood Cultures.
Antimicrobial Agents and Chemotherapy 2019 May 14
We assessed the antimicrobial-inactivation capability of BACT/ALERT® (FA Plus and FN Plus) or BACTEC™ (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic/bacterium combinations in simulated adult blood cultures. Besides high recovery rates (93.2% and 88.4%, respectively), we showed that at lowest but clinically relevant antibiotic concentrations, both BACT/ALERT® and BACTEC™ media recovered all the organisms when tested with drugs except for Escherichia coli tested in the presence of meropenem. Delayed recoveries mainly regarded vancomycin.
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