TAM Receptors in Cardiovascular Disease.

The TAM receptors are a distinct family of three receptor tyrosine kinases, namely Tyro3, Axl and MerTK. Since their discovery in the early 1990s, they have been studied for their ability to influence numerous diseases, including cancer, chronic inflammatory and autoimmune disorders, and cardiovascular diseases. The TAM receptors demonstrate an ability to influence multiple aspects of cardiovascular pathology via their diverse effects on cells of both the vasculature and the immune system. In this review we will explore the various functions of the TAM receptors and how they influence cardiovascular disease through regulation of vascular remodeling, efferocytosis and inflammation. Based on this information, we will suggest areas in which further research is required and identify potential targets for therapeutic intervention.