Odorless Isocyanide Chemistry：One-Pot Synthesis of Heterocycles via Passerini and the Post-Modification Tandem Reaction Based on In-situ Capture of Isocyanides.

This paper reports the tandem-reaction strategy of Passerini/Staudinger/aza-Wittig reaction based on the in-situ capture of isocyanides. According to this strategy, isocyanides are synthesized in situ, which immediately work as the substrate for Passerini reaction and post-modified tandem reaction in one-pot. In addition, two types new compounds of 5-oxo-3,5-dihydrobenzo[e][1,4] oxazepines and 6-oxo-5,6-dihydro-2H-1,4-oxazines were synthesized using the tandem-reaction strategy which undergos five-step transformations in one-pot.