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Journal Article
Research Support, N.I.H., Extramural
Lipid Peroxidation Adds Fuel to Pyr(optosis).
Cell Host & Microbe 2018 July 12
Glutathione peroxidase 4 (GPX4) is an antioxidant enzyme that protects cells from lipid peroxidation. In this issue of Cell Host & Microbe, Kang et al. (2018) report that GPX4 is a negative regulator of the pyroptotic cell death pathway and plays an important role in inhibiting lethal inflammation associated with sepsis.
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