[A Meta-analysis of comparing effectiveness and safety between minimally invasive video-assisted thyroidectomy and conventional thyroidectomy in the treatment of papillary thyroid carcinoma without lymph node metastasis].

Objective: To compare the effectiveness and safety between minimally invasive video-assisted thyroidectomy (MIVAT) and conventional thyroidectomy (CT) in the treatment of papillary thyroid carcinoma without lymph node metastasis, providing clinicians using video-assisted way to treat thyroid papillary carcinoma with a more reasonable basis. Method: According to the including and excluding criterion,we searched the published articles which compare the effectiveness of MIVAT and CT curing PTC in randomized controlled clinical trials. The searching time was from January 2011 to December 2016, and the data was analyzed by using revman 5.3 software. Result: Twelve articles involving 1 080 cases were included,and there were 514 cases in the MIVAT group and 566 cases in the CT group. The results of metaanalysis showed that: the operation time of MIVAT group is longer than that of CT group ( MD =17.19, 95% CI 12.43-21.96, P <0.05); however the VAS point of MIVAT group is less than that of CT group in twentyfour hours after surgery ( MD -1.07, 95% CI -1.61--0.53, P <0.05). There is no significant difference in the incidences of transient recurrent laryngeal nerve injury( OR =2.21,95% CI 0.9-5.07, P >0.05),transient hypoparathyroidism ( OR =0.78, 95% CI 0.48-1.28, P >0.05), serum thyroglobulin after five years followed up ( MD -0.05, 95% CI -0.25-0.16, P >0.05), number of retrieved central lymph nodes ( MD =-0.36, 95% CI -0.72-0.01, P >0.05) and number of retrieved central positive lymph nodes ( MD =-0.15, 95%CI -0.45-0.16, P >0.05). Conclusion: Using MIVAT treating papillary thyroid carcinoma (without lymph node metastasis) is safe when its indications are strictly controlled.