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Bond with Me If You Can! Natural Product, Covalent Ligand, and Reactivity-Based Probe Compete for Cysteine in PP2A Complex.
Cell Chemical Biology 2017 November 17
In this issue of Cell Chemical Biology, Grossman et al. (2017) disclose a chemoproteomics-enabled strategy to identify the cysteine-reactive target(s) of the anti-cancer natural product withaferin A and then screen a cysteine-reactive fragment library to discover a covalent ligand for the same target.
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