[Multiple lncRNAs affect the incidence and development of melanoma].

OBJECTIVE: To find the relationship between long non-coding RNA (lncRNA) based on data mining methods.
 Methods: We use a whole genome mRNA expression data set (GSE15605) from the gene expression ominibus database to find the lncRNAs which relate to melanoma.
 Results: Four lncRNAs (LINC01213, PGM5-AS1, LINC01133 and LOC284578) were significantly associated with the incidence and development of melanoma. Meanwhile, LINC01213, LINC01133 and LOC284578 were correlated with BRAF mutation, and PGM5-AS1 was related to NRAS mutation. Data mining study found that the model based on the expression values of these 4 lncRNAs can easily preferable classify the study samples.
 Conclusion: LncRNAs may play important roles in the incidence and development of melanoma.