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Journal Article
Research Support, Non-U.S. Gov't
Data-Driven Methods for the Determination of Anterior-Posterior Motion in PET.
IEEE Transactions on Medical Imaging 2017 Februrary
Physiological motion combined with elongated scanning times in PET leads to image degradation and quantification errors. Correction approaches usually require 1-D signals that can be obtained with hardware-based or data-driven methods. Most of the latter are optimized or limited to capture internal motion along the superior-inferior (S-I) direction. In this work we present methods for also extracting anterior-posterior (A-P) motion from PET data and propose a set of novel weighting mechanisms that can be used to emphasize certain lines-of-response (LORs) for an increased sensitivity and better signal-to-noise ratio (SNR). The proper functioning of the methods was verified in a phantom experiment. Further, their application to clinical [18F ]-FDG-PET data of 72 patients revealed that using the weighting mechanisms leads to signals with significantly higher spectral respiratory weights, i.e. signals with higher quality. Information about multi-dimensional motion is contained in PET data and can be derived with data-driven methods. Motion models or correction techniques such as respiratory gating might benefit from the proposed methods as they allow to describe the three-dimensional movements of PET-positive structures more precisely.
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