JOURNAL ARTICLE
REVIEW

[Epigenetics in allergic diseases and asthma]

José A Castro-Rodríguez, Bernardo J Krause, Ricardo Uauy, Paola Casanello
Revista Chilena de Pediatría 2016, 87 (2): 88-95
27055949
Allergic diseases and asthma are the result of complex interactions between genetic predisposition and environmental factors. Asthma is one of the most prevalent chronic disease among children. In this article we review some environmental factors like: allergen exposition, tobacco, bacteria, microbial components, diet, obesity and stress, which influences during intrauterine and infancy life in the epigenetic regulation of asthma and allergic diseases. The review has been done in three models: in-vitro, animal and human.

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