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[Valproate-induced hyperammonemic encephalopathy in a neonate: treatment with carglumic acid].

B Fernández Colomer, S Rekarte García, J E García López, C Pérez González, M Montes Granda, G D Coto Cotallo
Anales de Pediatría : Publicación Oficial de la Asociación Española de Pediatría (A.E.P.) 2014 October
Valproate-induced hyperammonemic encephalopathy (VHE) is an unusual and serious complication of valproate (VA) treatment. When an early diagnosis is made, it can be reversed with VA withdrawal and early treatment for hyperammonemia. We describe the case of a 20 days old male, who developed a serious VHE after receiving VA for refractory neonatal seizures. The VHE was resolved with VA withdrawal in association with carglumic acid and other measures for hyperammonemia treatment.

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