JOURNAL ARTICLE

Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes

Zach Nadler, Bo Wang, Gadi Wollstein, Jessica E Nevins, Hiroshi Ishikawa, Larry Kagemann, Ian A Sigal, R Daniel Ferguson, Daniel X Hammer, Ireneusz Grulkowski, Jonathan J Liu, Martin F Kraus, Chen D Lu, Joachim Hornegger, James G Fujimoto, Joel S Schuman
Biomedical Optics Express 2013, 4 (11): 2596-608
24298418
We demonstrate an automated segmentation method for in-vivo 3D optical coherence tomography (OCT) imaging of the lamina cribrosa (LC). Manual segmentations of coronal slices of the LC were used as a gold standard in parameter selection and evaluation of the automated technique. The method was validated using two prototype OCT devices; each had a subject cohort including both healthy and glaucomatous eyes. Automated segmentation of in-vivo 3D LC OCT microstructure performed comparably to manual segmentation and is useful for investigative research and in clinical quantification of the LC.

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