We have located links that may give you full text access.
English Abstract
Journal Article
Meta-Analysis
[Effectiveness of norepinephrine versus dopamine for septic shock: a meta analysis].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2013 August
OBJECTIVE: To systematically evaluate the effect of norepinephrine and dopamine on patients with septic shock.
METHODS: Randomized controlled trials (RCTs) about treatment of adults with septic shock with norepinephrine and dopamine were selected from PubMed, Embase, the Cochrane Library, CBM and CNKI databases. Meta analysis concerning the effect of norepinephrine and dopamine on hemodynamics and metabolism of patients with septic shock was conducted by using Review Manager 5.0 software. The results were expressed as risk ratio (RR) for dichotomous outcomes or standardized mean difference (SMD) for continuous data with 95% confidence intervals (95%CI).
RESULTS: Eleven trials with 1718 cases were enrolled. Meta analysis showed that compared with dopamine, norepinephrine could decrease the mortality (RR=0.89, 95%CI 0.81-0.98, P=0.02). There were a decreased heart rate (SMD=-2.23, 95%CI -3.76 to -0.71, P=0.004), cardiac index (SMD=-0.71, 95%CI -1.07 to -0.35, P=0.0001) and an increased systemic vascular resistance index (SMD=1.39, 95%CI 0.54-2.23, P=0.001) were found in norepinephrine group compared with dopamine group. However, there were no significant differences on the effect of mean artery pressure (SMD=0.64, 95%CI -1.09-2.38, P=0.47), oxygen delivery (SMD=-0.54, 95%CI -1.50-0.42, P=0.27), oxygen consumption(SMD=-0.49, 95%CI -1.37-0.39, P=0.27) and lactic acid (SMD=-0.24, 95%CI -0.90-0.42, P=0.48) between these two vasopressors.
CONCLUSIONS: Norepinephrine is associated with an improved hemodynamics and decreased mortality compared with dopamine in septic shock patients.
METHODS: Randomized controlled trials (RCTs) about treatment of adults with septic shock with norepinephrine and dopamine were selected from PubMed, Embase, the Cochrane Library, CBM and CNKI databases. Meta analysis concerning the effect of norepinephrine and dopamine on hemodynamics and metabolism of patients with septic shock was conducted by using Review Manager 5.0 software. The results were expressed as risk ratio (RR) for dichotomous outcomes or standardized mean difference (SMD) for continuous data with 95% confidence intervals (95%CI).
RESULTS: Eleven trials with 1718 cases were enrolled. Meta analysis showed that compared with dopamine, norepinephrine could decrease the mortality (RR=0.89, 95%CI 0.81-0.98, P=0.02). There were a decreased heart rate (SMD=-2.23, 95%CI -3.76 to -0.71, P=0.004), cardiac index (SMD=-0.71, 95%CI -1.07 to -0.35, P=0.0001) and an increased systemic vascular resistance index (SMD=1.39, 95%CI 0.54-2.23, P=0.001) were found in norepinephrine group compared with dopamine group. However, there were no significant differences on the effect of mean artery pressure (SMD=0.64, 95%CI -1.09-2.38, P=0.47), oxygen delivery (SMD=-0.54, 95%CI -1.50-0.42, P=0.27), oxygen consumption(SMD=-0.49, 95%CI -1.37-0.39, P=0.27) and lactic acid (SMD=-0.24, 95%CI -0.90-0.42, P=0.48) between these two vasopressors.
CONCLUSIONS: Norepinephrine is associated with an improved hemodynamics and decreased mortality compared with dopamine in septic shock patients.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app