JOURNAL ARTICLE

Analysis of time course Omics datasets

Martin G Grigorov
Methods in Molecular Biology 2011, 719: 153-72
21370083
Over the past 20 years, Omics technologies emerged as the consensual denomination of holistic molecular profiling. These techniques enable parallel measurements of biological -omes, or "all constituents considered collectively", and utilize the latest advancements in transcriptomics, proteomics, metabolomics, imaging, and bioinformatics. The technological accomplishments in increasing the sensitivity and throughput of the analytical devices, the standardization of the protocols and the widespread availability of reagents made the capturing of static molecular portraits of biological systems a routine task. The next generation of time course molecular profiling already allows for extensive molecular snapshots to be taken along the trajectory of time evolution of the investigated biological systems. Such datasets provide the basis for application of the inverse scientific approach. It consists in the inference of scientific hypotheses and theories about the structure and dynamics of the investigated biological system without any a priori knowledge, solely relying on data analysis to unveil the underlying patterns. However, most temporal Omics data still contain a limited number of time points, taken over arbitrary time intervals, through measurements on biological processes shifted in time. The analysis of the resulting short and noisy time series data sets is a challenge. Traditional statistical methods for the study of static Omics datasets are of limited relevance and new methods are required. This chapter discusses such algorithms which enable the application of the inverse analysis approach to short Omics time series.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
21370083
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"