[Impending Coumarin-necrosis in a patient with heterozygous protein C deficiency type I]

R Schulze, W Behr, H Wittwer, S Harwix, K Murmann, W V Scheidt, W Ehret, G Schlimok
Der Internist 2008, 49 (5): 618, 620, 621-22
Painful pink or magenta colored skin lesions characterized by a clear line of demarcation between the affected area and surrounding tissue appearing under therapy with coumarins may be a sign for evolving coumarin-necrosis. Immediate treatment with a protein C preparation in patients with protein C deficiency can prevent necrosis.

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