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Role of coagulation factor XIII (FXIII) in angiogenesis and tissue repair.

Aida Inbal, Rima Dardik
Pathophysiology of Haemostasis and Thrombosis 2006
Factor FXIII (FXIII) is a plasma transglutaminase that catalyzes the cross link formation between fibrin chains to stabilize the clot. Beside it s function in hemostasis FXIII has a role in wound healing and embryo implantation--processes that involve angiogenesis. In this review we discuss the role of FXIII in angiogenesis and the molecular mechanisms underlying its pro-angiogenic effect. In addition, FXIII role in wound repair is discussed.

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