Relationship between paraoxonase-1 (PON1) activity and lipoprotein (a) levels in Turkish coronary artery disease patients living in the Antalya region.

Yeşim A Göçmen, Ender Semiz, Saadet Gümüşlü

European Journal of Cardiovascular Prevention and Rehabilitation 2005 April

BACKGROUND: Turkish adults have a high incidence of coronary artery disease (CAD).

DESIGN: The role of lipoprotein(a) (Lp[a]) as a risk factor for CAD and its association with paraoxonase-1 (PON1) activity and lipid peroxidation indicators were evaluated in Turkish subjects living in Antalya.

METHODS: Paraoxonase-1 activity, Lp(a), conjugated dienes (CD) and thiobarbituric acid-reactive substances (TBARS) levels were measured in 45 healthy controls and 72 CAD patients.

RESULTS: In CAD patients, decreased PON1 activity and increased Lp(a), CD and TBARS levels were observed. Risk factors associated with CAD included TBARS, age and CD.

CONCLUSIONS: Our results indicate an association between PON1 activity and Lp(a) level in CAD patients.

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