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JOURNAL ARTICLE
Fan-Fan Wang, Ping-Fang Tao, Yu-Jun Zhong, Yun-Qiong Gu, Cai Yi Wang, Feng Qin
Zanthoxylum nitidum is frequently used as a traditional Chinese medicine and food supplement. Our previous study revealed that its constituent compounds were able to inhibit cancer cell proliferation. In our continuous exploration of bioactive compounds in Z. nitidum , we isolated ten alkaloids ( 1 - 10 ), including one new natural compound ( 1 ), and nine known alkaloids ( 2-10 ), from an ethanolic extract of the whole plant. The chemical structures were elucidated based on a combination of comprehensive NMR and HRESIMS analyses...
April 29, 2024: Natural Product Research
#2
JOURNAL ARTICLE
Zsuzsanna Bordan, Robert Batori, Stephen Haigh, Xueyi Li, Mary Louise Meadows, Zach L Brown, Madison A West, Kunzhe Dong, Weihong Han, Yunchao Su, Qian Ma, Yuqing Huo, Jiliang Zhou, Mahmoud Abdelbary, Jennifer Sullivan, Neal L Weintraub, David W Stepp, Feng Chen, Scott A Barman, David J R Fulton
BACKGROUND: Pulmonary arterial hypertension (PAH) is high blood pressure in the lungs that originates from structural changes in small resistance arteries. A defining feature of PAH is the inappropriate remodeling of pulmonary arteries (PA) leading to right ventricle failure and death. Although treatment of PAH has improved, the long-term prognosis for patients remains poor, and more effective targets are needed. METHODS: Gene expression was analyzed by microarray, RNA sequencing, quantitative polymerase chain reaction, Western blotting, and immunostaining of lung and isolated PA in multiple mouse and rat models of pulmonary hypertension (PH) and human PAH...
April 29, 2024: Circulation
#3
Francesco Foglia, Giuseppe Greco, Carla Zannella, Annalisa Chianese, Annalisa Ambrosino, Alessandra Conzo, Giovanni Conzo, Anna De Filippis, Emiliana Finamore, Ludovico Docimo, Massimiliano Galdiero
Magnusiomyces capitatus (M. capitatus) is an emerging opportunistic yeast in the Mediterranean region typically isolated from immunocompromised patients, usually affected by blood malignancies. We reported a rare case of M. capitatus infection, isolated from a drainage fluid in a patient affected by lung cancer recovered in the University Hospital of Campania "Luigi Vanvitelli", Naples, Italy. The isolate was identified by phenotypic methods, i.e., Gram and Lactophenol cotton blue (LCB) staining, and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis...
2024: IDCases
#4
JOURNAL ARTICLE
Laura Alder, Gloria Broadwater, Michelle Green, Amanda E D Van Swearingen, Eric S Lipp, Jeffrey Melson Clarke, Carey K Anders, Sarah Sammons
BACKGROUND: Although serum circulating tumor DNA (ctDNA) is routine, data from patients with brain metastases (BrMs) is limited. We assessed genomic alterations in ctDNA from patients with solid tumor BrMs in 3 groups: Isolated BrMs with stable extracranial disease (iCNS), concurrent brain and extracranial progression (cCNS), and extracranial progression with no active BrMs (eCNS). We also compared ctDNA alterations between patients with and without BrMs. METHODS: Patients with a Guardant360 ctDNA profile with ( n = 253) and without BrMs ( n = 449) from the Duke Molecular Registry between January 2014 and December 2020 were identified...
2024: Neuro-oncology advances
#5
JOURNAL ARTICLE
Achara Raksat, Md Samiul Huq Atanu, Sheyanne Mendez, Rafael de la Zerda, Rui Sun, Sarot Cheenpracha, Marisa Wall, Charles J Simmons, Philip G Williams, Ghee T Tan, Supakit Wongwiwatthananukit, Leng Chee Chang
The fruit extract of Melaleuca quinquenervia yielded a total of 19 compounds, including two novel spiro-biflavonoid enantiomers ( 1a and 1b ) and a chalcone derivative ( 3 ). Their structures were determined through spectroscopic analysis. The enantiomers of the racemic mixture of compound 1 were successfully resolved into (+)- 1 and (-)- 1 using chiral-phase HPLC. Single-crystal X-ray diffraction analysis was also used to confirm the structure of 1 . The enantiomeric configurations of 1 and 2 were determined through a comparison of the calculated and experimental electronic circular dichroism spectra...
April 23, 2024: ACS Omega
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JOURNAL ARTICLE
Ekaterina Lenchenko, Nadezhda Sachivkina, Olesya Petrukhina, Nikolay Petukhov, Andrey Zharov, Natallia Zhabo, Marina Avdonina
BACKGROUND AND AIM: The pathogenesis of staphylococcal infections is mediated by virulence factors, such as enzymes, toxins, and biofilms, which increase the resistance of microorganisms to host immune system evasion. Testing and searching for standardized multi-level algorithms for the indication and differentiation of biofilms at the early stages of diagnosis will contribute to the development of preventive measures to control the critical points of technology and manage dangerous risk factors for the spread of infectious diseases...
March 2024: Veterinary World
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JOURNAL ARTICLE
Audra J Reiter, Lynn Huang, Brian T Craig, Andrew M Davidoff, Lindsay J Talbot, Jordan Coggins, Jasmine Smith, Jennifer H Aldrink, Katherine C Bergus, Taleen A MacArthur, Stephanie F Polites, Chloe Boehmer, Joseph Brungardt, Marcus M Malek, Hannah N Rinehardt, Zachary J Kastenberg, Cameron M Arkin, Antoine Gourmel, Nelson Piche, Marshall Wallace, Jiancong Liang, Harold N Lovvorn, Robin T Petroze, Gwendolyn Gillies, John P Marquart, Kerri Becktell, Hau D Le, Juan Favela, Barrie S Rich, Richard D Glick, Natashia M Seemann, Jacob Davidson, Claire A Wilson, Jonathan Roach, Erin G Brown, Kathleen E Doyle, Brian A Coakley, Pamela Emengo, Pamela Merola, Christa N Grant, Anuritha Tirumani, Elisabeth T Tracy, Mary E Moya-Mendez, Roshni Dasgupta, Timothy B Lautz
PURPOSE: Our objectives were to compare overall survival (OS) and pulmonary relapse between patients with metastatic Ewing sarcoma (EWS) at diagnosis who achieve rapid complete response (RCR) and those with residual pulmonary nodules after induction chemotherapy (non-RCR). PATIENTS AND METHODS: This retrospective cohort study included children under 20 years with metastatic EWS treated from 2007 to 2020 at 19 institutions in the Pediatric Surgical Oncology Research Collaborative...
April 28, 2024: Pediatric Blood & Cancer
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JOURNAL ARTICLE
Javier Milara, Inés Roger, Paula Montero, Enrique Artigues, Juan Escrivá, Raquel Del Río, Julio Cortijo
BACKGROUND AND PURPOSE: IL-11 is a member of the IL-6 family of cytokine initially considered as haematopoietic and cytoprotective factor. Recent evidence indicates that IL-11 promotes lung fibrosis and pulmonary hypertension in animal models and is elevated in lung tissue of patients with pulmonary fibrosis and pulmonary hypertension. Fibrocytes are bone marrow-derived circulating cells that participate in lung fibrosis and pulmonary hypertension, but the role of IL-11 on fibrocytes is unknown...
April 28, 2024: British Journal of Pharmacology
#9
JOURNAL ARTICLE
Hui Zhang, Di Liu, Qing-Feng Xu, Juan Wei, Ying Zhao, Dun-Feng Xu, Yan Wang, Yu-Jian Liu, Xiao-Yan Zhu, Lai Jiang
Endothelial repair is essential for restoring tissue fluid homeostasis following lung injury. R-spondin3 (RSPO3), a secreted protein mainly produced by endothelial cells (ECs), has shown its protective effect on endothelium. However, the specific mechanisms remain unknown. To explore whether and how RSPO3 regulates endothelial regeneration after inflammatory vascular injury, the role of RSPO3 in sepsis-induced pulmonary endothelial injury was investigated in EC-specific RSPO3 knockdown, inducible EC-specific RSPO3 deletion mice, EC-specific RSPO3 overexpression mice, systemic RSPO3-administration mice, in isolated mouse lung vascular endothelial cells (MLVECs), and in plasma from septic patients...
April 25, 2024: International Journal of Biological Macromolecules
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JOURNAL ARTICLE
Karima Gourari-Bouzouina, Zahia Boucherit-Otmani, Abdelfettah Seghir, Zahira Zakia Baba Ahmed-Kazi Tani, Imene Bendoukha, Abdeselem Benahmed, Mohammed Aissaoui, Kebir Boucherit
Cystic fibrosis patients' lungs are chronically colonized by multiple microbial species capable of forming biofilms. This study aimed to characterize the polymicrobial biofilm formed by Candida spp. and S. aureus, co-isolated from sputum samples of cystic fibrosis patients regarding microbial density, metabolic activity, and structure. 67 samples from 28 patients were collected with a 96% alteration rate. 34% showed alterations by both Candida spp. and Gram-positive bacteria, predominantly Candida spp. and S...
April 26, 2024: Diagnostic Microbiology and Infectious Disease
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JOURNAL ARTICLE
Mehmet Mustafa Özaslan, Gökçen Kartal Öztürk, Meral Barlik, Ece Ocak, Fevziye Çoksuer, Bahar Girgin Dindar, Atacan Öğütçü, Ece Halis, Esen Demir, Figen Gülen
INTRODUCTION: Flexible bronchoscopy is a valuable method in the diagnosis and treatment of respiratory tract diseases in children. This study aimed to examine the indications for and results of flexible bronchoscopy in children. MATERIALS AND METHODS: The study included patients aged 0-18 years who underwent flexible bronchoscopy between 1 January 2017 and 31 December 2022. The patients were evaluated for demographic characteristics, indications for bronchoscopy, comorbidities, bronchoscopy findings, and the results of bronchoalveolar lavage...
March 2024: Tüberküloz Ve Toraks
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JOURNAL ARTICLE
Albatoul S Althenayan, Shada A AlSalamah, Sherin Aly, Thamer Nouh, Bassam Mahboub, Laila Salameh, Metab Alkubeyyer, Abdulrahman Mirza
Coronavirus disease 2019 (COVID-19), originating in China, has rapidly spread worldwide. Physicians must examine infected patients and make timely decisions to isolate them. However, completing these processes is difficult due to limited time and availability of expert radiologists, as well as limitations of the reverse-transcription polymerase chain reaction (RT-PCR) method. Deep learning, a sophisticated machine learning technique, leverages radiological imaging modalities for disease diagnosis and image classification tasks...
April 20, 2024: Sensors
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JOURNAL ARTICLE
Aruna Ambagala, Kalhari Goonewardene, Ian El Kanoa, Thi Tam Than, Van Tam Nguyen, Thi Ngoc Ha Lai, Thi Lan Nguyen, Cassidy N G Erdelyan, Erin Robert, Nikesh Tailor, Chukwunonso Onyilagha, Lindsey Lamboo, Katherine Handel, Michelle Nebroski, Oksana Vernygora, Oliver Lung, Van Phan Le
In this paper, we report the characterization of a genetically modified live-attenuated African swine fever virus (ASFV) field strain isolated from Vietnam. The isolate, ASFV-GUS-Vietnam, belongs to p72 genotype II, has six multi-gene family (MGF) genes deleted, and an Escherichia coli GusA gene (GUS) inserted. When six 6-8-week-old pigs were inoculated with ASFV-GUS-Vietnam oro-nasally (2 × 105 TCID50 /pig), they developed viremia, mild fever, lethargy, and inappetence, and shed the virus in their oral and nasal secretions and feces...
April 7, 2024: Viruses
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JOURNAL ARTICLE
Antiviral Effect of Antimicrobial Peptoid TM9 and Murine Model of Respiratory Coronavirus Infection.
Maxim Lebedev, Aaron B Benjamin, Sathish Kumar, Natalia Molchanova, Jennifer S Lin, Kent J Koster, Julian L Leibowitz, Annelise E Barron, Jeffrey D Cirillo
New antiviral agents are essential to improving treatment and control of SARS-CoV-2 infections that can lead to the disease COVID-19. Antimicrobial peptoids are sequence-specific oligo- N -substituted glycine peptidomimetics that emulate the structure and function of natural antimicrobial peptides but are resistant to proteases. We demonstrate antiviral activity of a new peptoid (TM9) against the coronavirus, murine hepatitis virus (MHV), as a closely related model for the structure and antiviral susceptibility profile of SARS-CoV-2...
March 27, 2024: Pharmaceutics
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JOURNAL ARTICLE
Beatrice Mihaela Tivadar, Traian Dumitrascu, Catalin Vasilescu
Background : Many papers exploring the role of resectioning metastases in colorectal cancer (CRC) have focused mainly on liver and lung sites, showing improved survival compared with non-resectional therapies. However, data about exceptional metastatic sites such as splenic metastases (SMs) are scarce. This paper aims to assess the role and effectiveness of splenectomy in the case of isolated metachronous SM of CRC origin. Methods : The patients' data were extracted after a comprehensive literature search through public databases for articles reporting patients with splenectomies for isolated metachronous SM of CRC origin...
April 18, 2024: Journal of Clinical Medicine
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JOURNAL ARTICLE
Tatiana Gerashchenko, Rostislav Skitchenko, Anastasia Korobeynikova, Kristina Kuanysheva, Anna Khozyainova, Rostislav Vorobiev, Evgeny Rodionov, Sergey Miller, Evgeny Topolnitsky, Nikolay Shefer, Maxim Anisimenko, Lilia Zhuikova, Mrinal Vashisth, Olga Pankova, Vladimir Perelmuter, Valeria Rezapova, Mykyta Artomov, Evgeny Denisov
Early prediction and prevention of recurring illness is critical for improving the survival rates of patients with non-small cell lung cancer (NSCLC). Previously, we demonstrated that the presence of premalignant epithelial changes in the small bronchi distant to the primary tumor is associated with NSCLC progression: isolated basal cell hyperplasia (iBCH) indicates a high risk of distant metastasis, BCH combined with squamous metaplasia (BCHSM ) - a high risk of locoregional recurrence. Here, we aimed to identify germline single nucleotide variants (SNVs) and insertions and deletions (InDels) associated with distant metastasis and locoregional recurrence in cases with iBCH and BCHSM using whole-exome sequencing of 172 NSCLC patients...
April 24, 2024: Gene
#17
JOURNAL ARTICLE
Dan Luo, Fang He, Jingyun Liu, Xueting Dong, Mengying Fang, Yuling Liang, Mengqin Chen, Xuemei Gui, Wenjun Wang, Li Zeng, Xianming Fan, Qibiao Wu
Pseudolaric acid B (PAB), an acid isolated from the roots of Pseudolarix kaempferi gorden, has shown antitumour effects through multiple mechanisms of action. The objective of this study was to investigate the anticancer effect of PAB on non-small cell lung cancer (NSCLC) and its underlying mechanism. In our experiments, we observed that PAB decreased cell viability, inhibited colony formation, induced cell cycle arrest, impeded scratch healing, and increased apoptosis in H1975 and H1650 cells. Additionally, PAB treatment enhanced the fluorescence intensity of MDC staining in NSCLC cells, upregulated the protein expression of microtubule-associated protein light chain 3 II (LC3 II), and downregulated the expression of sequestosome 1 (SQSTM1/P62)...
April 25, 2024: Biomedicine & Pharmacotherapy
#18
JOURNAL ARTICLE
Francesco Palumbo, Miša Gunjak, Patty J Lee, Stefan Günther, Anne Hilgendorff, István Vadász, Susanne Herold, Werner Seeger, Christian Mühlfeld, Rory E Morty
Flow cytometry and fluorescence-activated cell sorting are widely used to study endothelial cells, for which the generation of viable single-cell suspensions is an essential first step. Two enzymatic approaches, collagenase A and dispase, are widely employed for endothelial cell isolation. In this study, the utility of both enzymatic approaches, alone and in combination, for endothelial cell isolation from juvenile and adult mouse lungs was assessed, considering the number, viability, and subtype composition of recovered endothelial cell pools...
April 26, 2024: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
#19
JOURNAL ARTICLE
Bruno Cesar Costa Soares, Hnin Ei Ei Khine, Boonchoo Sritularak, Pithi Chanvorachote, Rosa Alduina, Rungroch Sungthong, Chatchai Chaotham
Background: The upgrade of natural products for cancer treatment is essential since current anticancer drugs still pose severe side effects. Cymensifin A (Cym A) isolated from an orchid Cymbidium ensifolium has shown its potential to induce the death of several cancer cells; however, its underlying molecular mechanisms are hitherto unknown. Methods: Here, we conducted a set of in vitro preliminary tests to assess the cytotoxic effects of Cym A on non-small-cell lung cancer (NSCLC) cells (A549, H23, H292, and H460)...
2024: Frontiers in Pharmacology
#20
JOURNAL ARTICLE
Shia Vang, Eric Scott Helton, Yiming Guo, Bailey Burpee, Elex Rose, Molly Easter, Seth Bollenbecker, Meghan June Hirsch, Emma Lea Matthews, Luke Isaac Jones, Patrick Henry Howze, Vasanthi Rajasekaran, Rebecca Denson, Phillip Cochran, Isaac Kwame Attah, Heather Olson, Geremy Clair, Girish Melkani, Stefanie Krick, Jarrod Wesley Barnes
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic pulmonary disease that is characterized by an excessive accumulation of extracellular matrix (ECM) proteins (e.g. collagens) in the parenchyma, which ultimately leads to respiratory failure and death. While current therapies exist to slow the progression, no therapies are available to resolve fibrosis. METHODS: We characterized the O-linked N-Acetylglucosamine (O-GlcNAc) transferase (OGT)/O-GlcNAc axis in IPF using single-cell RNA-sequencing (scRNA-seq) data and human lung sections and isolated fibroblasts from IPF and non-IPF donors...
2024: Frontiers in Immunology
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