Maria González-Cao, Xueting Cai, Jilian Wilhelmina Paulina Bracht, Xuan Han, Yang Yang, Carlos Pedraz-Valdunciel, Teresa Morán, Javier García-Corbacho, Andrés Aguilar, Reyes Bernabé, Pedro De Marchi, Luciane Sussuchi da Silva, Leticia Ferro Leal, Rui Manuel Reis, Jordi Codony-Servat, Eloisa Jantus-Lewintre, Miguel Angel Molina-Vila, Peng Cao, Rafael Rosell
PURPOSE: High-mobility group box 1 protein (HMGB1) is subject to exportin 1 (XPO1)-dependent nuclear export, and it is involved in functions implicated in resistance to immunotherapy. We investigated whether HMGB1 mRNA expression was associated with response to immune checkpoint inhibitors (ICI) in non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: RNA was isolated from pretreatment biopsies of patients with advanced NSCLC treated with ICI. Gene expression analysis of several genes, including HMGB1, was conducted using the NanoString Counter analysis system (PanCancer Immune Profiling Panel)...
2024: Lung Cancer: Targets and Therapy