Yuhong Ou, Hongtao Luo, Qiuning Zhang, Tianqi Du, Ruifeng Liu, Dandan Wang, Junru Chen, Meng Dong, Yuhang Wang, Zhen Yang, Xiaohu Wang
BACKGROUND: Gliomas are characterized by aggressive behavior, leading to severe disability and high mortality. Ubiquitin-like modifier activating enzyme 2 (UBA2) is a subunit of the E1-activating enzyme involved in the SUMOylation (SUMO, small ubiquitin-related modifier) of numerous proteins. Although the abnormality of UBA2 is linked to the progression of various tumor types, the role of UBA2 in glioma is still unknown. METHODS: A bioinformatic analysis using several public databases was conducted to examine the expression level, clinicopathological correlations, and prognostic significance of UBA2 in glioma...
April 9, 2024: Frontiers in Bioscience (Landmark Edition)