Xianzun Tao, Jiaqi Liu, Zoraida Diaz-Perez, Jackson R Foley, Ashley Nwafor, Tracy Murray Stewart, Robert A Casero, R Grace Zhai
Precise polyamine metabolism regulation is vital for cells and organisms. Mutations in spermine synthase (SMS) cause Snyder-Robinson intellectual disability syndrome (SRS), characterized by significant spermidine accumulation and autophagy blockage in the nervous system. Emerging evidence connects polyamine metabolism with other autophagy-related diseases, such as Tauopathy, however, the functional intersection between polyamine metabolism and autophagy in the context of these diseases remains unclear. Here, we altered SMS expression level to investigate the regulation of autophagy by modulated polyamine metabolism in Tauopathy in Drosophila and human cellular models...
May 13, 2024: Cell Death & Disease