Joseph W Jackson, Pravin R Kaldhone, Leonid A Parunov, Caitlin F Stewart, John G Anderson, Scott J MacGregor, Michelle Maclean, Chintamani D Atreya
Chemical and UV light-based pathogen reduction technologies are currently in use for human platelet concentrates (PCs) to enhance safety from transfusion-transmitted infections. Relative to UV light, 405 nm violet-blue light in the visible spectrum is known to be less harmful. Hence, in this report for the first time, we have assessed the global hemostasis activity of PCs stored in plasma and the activities of six plasma coagulation factors (CFs) as a measure of in vitro hemostatic activity following exposure to the microbicidal 405 nm light...
April 23, 2024: Journal of Photochemistry and Photobiology. B, Biology