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REVIEW
Xueqin Chen, Xiao Song, Hui Huang, Lian Zhang, Zhiqiang Song, Xichuan Yang, Shanchuan Lei, Zhifang Zhai
PURPOSE: Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin, which mainly occurs in the sun exposed sites of white patients over 65 years, with a higher recurrence and metastasis rate. Clinically, MCC overlapping Bowen's disease (BD) is a very rare subtype of MCC. Few cases in the literature have been described and the management is not well defined. We summarize and update the epidemiology, clinical and histopathological features, metastasis characteristics, local recurrence rate and management of it by presenting two cases of MCC overlapping BD and reviewing the literature over the last 11 years...
April 26, 2024: Journal of Cancer Research and Clinical Oncology
#2
MULTICENTER STUDY
Valeria Fabre, Sara E Cosgrove, Fernanda C Lessa, Twisha S Patel, Guadalupe Reyes-Morales, Washington R Aleman, Andrea Alvarado Alvarez, Bowen Aquiles, Ana B Arauz, Facundo Arguello, Maria Fernanda Barberis, Laura Barcan, Maria P Bernachea, Marisa L Bernan, Carlos Buitrago, Maria Del Carmen Bangher, Ximena Castañeda, Angel M Colque, Alfredo Canton, Rosa Contreras, Silvia Correa, Gustavo Costilla Campero, Lidia Espinola, Clara Esquivel, Cecilia Ezcurra, Leandro A Falleroni, Johana Fernandez, Sandra Ferrari, Natalia Frassone, Carlos Garcia Cruz, Maria Isabel Garzón, Carlos H Gomez Quintero, José A Gonzalez, Lucrecia Guaymas, Fausto Guerrero-Toapanta, Sandra Lambert, Diego Laplume, Paola R Lazarte, César G Lemir, Angelica Lopez, Itzel L Lopez, Herberth Maldonado, Guadalupe Martinez, Diego M Maurizi, Mario Melgar, Florencia Mesplet, Carlos Morales Pertuz, Cristina Moreno, Gabriela L Moya, Yanina Nuccetelli, Glendys Núñez, Carolina Osuna, Belén Palacio, Florencia Pellice, Carla Raffo, Fanny Reino Choto, Gerardo Ricoy, Viviana Rodriguez, Federico Romero, Juan J Romero, Maria Eugenia Russo, Graciela Sadino, Nancy Sandoval, Mirta G Silva, Alejandra M Urueña, Ligia Vence Reyes, Hugo Videla, Marisol Valle, Silvia Vera Amate Perez, Hernan Vergara-Samur, Silvina Villamandos, Olmedo Villarreal, Alejandra Viteri, Eduardo Warley, Rodolfo E Quiros
BACKGROUND: The burden of antimicrobial resistance (AMR) in Latin America is high. Little is known about healthcare workers' (HCWs) knowledge, attitudes, and perceptions of antimicrobial stewardship (AS), AMR, and antibiotic use (AU) in the region. METHODS: HCWs from 42 hospitals from 5 Latin American countries were invited to take an electronic, voluntary, anonymous survey regarding knowledge, attitudes, and perceptions of AS, AMR, and AU between March-April 2023...
April 26, 2024: Antimicrobial Resistance and Infection Control
#3
JOURNAL ARTICLE
Ouli Xie, Cameron Zachreson, Gerry Tonkin-Hill, David J Price, Jake A Lacey, Jacqueline M Morris, Malcolm I McDonald, Asha C Bowen, Philip M Giffard, Bart J Currie, Jonathan R Carapetis, Deborah C Holt, Stephen D Bentley, Mark R Davies, Steven Y C Tong
Streptococcus dysgalactiae subspecies equisimilis (SDSE) and Streptococcus pyogenes share skin and throat niches with extensive genomic homology and horizontal gene transfer (HGT) possibly underlying shared disease phenotypes. It is unknown if cross-species transmission interaction occurs. Here, we conduct a genomic analysis of a longitudinal household survey in remote Australian First Nations communities for patterns of cross-species transmission interaction and HGT. Collected from 4547 person-consultations, we analyse 294 SDSE and 315 S...
April 24, 2024: Nature Communications
#4
JOURNAL ARTICLE
Zhanhui Wang, Bowen Hu, Xiaoming Chen, Zheng Zhang, Lu Liu, Nan Li, Chun Liang
The osseous vascular endothelium encompasses a vast intricate framework that regulates bone remodeling. Osteoporosis, an age-associated systemic bone disease, is characterized by the degeneration of the vascular architecture. Nevertheless, the precise mechanisms underpinning the metamorphosis of endothelial cells (ECs) with advancing age remain predominantly enigmatic. In this study, we conducted a systematic analysis of differentially expressed genes (DEGs) and the associated pathways in juvenile and mature femoral ECs, utilizing data sourced from the Gene Expression Omnibus (GEO) repositories (GSE148804) and employing bioinformatics tools...
2024: Brazilian Journal of Medical and Biological Research
#5
JOURNAL ARTICLE
Bowen Jiang, Wei Zhang, Yu He, Zhen Wu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Anchun Cheng, Shun Chen
Duck Tembusu virus (DTMUV) belongs to the Flaviviridae family and mainly infects ducks. Duck Tembusu virus genome encodes one polyprotein that undergoes cleavage to produce 10 proteins. Among these, NS4B, the largest transmembrane protein, plays a crucial role in the viral life cycle. In this study, we investigated the localization of NS4B and found that it is located in the endoplasmic reticulum, where it co-localizes with DTMUV dsRNA. Subsequently, we confirmed 5 different transmembrane domains of NS4B and discovered that only its transmembrane domain 3 (TMD3) can traverse ER membrane...
April 3, 2024: Poultry Science
#6
JOURNAL ARTICLE
Giulia Bazzacco, Iris Zalaudek, Enzo Errichetti
INTRODUCTION: Over the few last decades, dermoscopy has become an invaluable and popular imaging technique that complements the diagnostic armamentarium of dermatologists, being employed for both tumors and inflammatory diseases. Whereas distinction between neoplastic and inflammatory lesions is often straightforward based on clinical data, there are some scenarios that may be troublesome, e.g., solitary inflammatory lesions or tumors superimposed to a widespread inflammatory condition that may share macroscopic morphological findings...
April 2024: Italian journal of dermatology and venereology
#7
JOURNAL ARTICLE
Denis Abramochkin, Bowen Li, Han Zhang, Ekaterina Kravchuk, Tatiana Nesterova, Grigory Glukhov, Anna Shestak, Elena Zaklyazminskaya, Olga S Sokolova
Brugada syndrome (BrS) is an inherited disease characterized by right precordial ST-segment elevation in the right precordial leads on electrocardiograms (ECG), and high risk of life-threatening ventricular arrhythmia and sudden cardiac death (SCD). Mutations in the responsible genes have not been fully characterized in the BrS patients, except for the SCN5A gene. We identified a new genetic variant, c.1189C>T (p.R397C), in the KCNH2 gene in the asymptomatic male proband diagnosed with BrS and mild QTc shortening...
March 2024: Biochemistry. Biokhimii︠a︡
#8
JOURNAL ARTICLE
Richard A Carr, James Wiggins, David N Slater
AIMS: Cutaneous follicular (infundibular-tricholemmal) squamous cell carcinoma (FSCC) is a new World Health Organization entity. We present the largest series of published cases, summarizing clinical data, diagnostic criteria, differential diagnosis, and implications for patient management. METHODS: Cases were identified from 2004 to 2011. Inclusion criteria included discrete attachment(s) of the tumor to the overlying epidermis via follicular infundibula, tricholemmal keratinization, and cellular pleomorphism...
April 23, 2024: American Journal of Dermatopathology
#9
JOURNAL ARTICLE
Shan Fang, Linglin Zhang, Peiru Wang, Lei Shi, Haiyan Zhang, Caihe Liao, Zijun Zhao, Zongxia Zhou, Yan Zhao, Guorong Yan, Yun Wu, Yuhao Wu, Zhe Zheng, Ruiping Wang, Yeqiang Liu, Guolong Zhang, Xiuli Wang
BACKGROUND: Photodynamic therapy (PDT) has been strongly recommended as an excellent alternative treatment for Bowen's disease (BD). However, reported data on 5-aminolevulinic acid-mediated PDT (ALA-PDT) with red light irradiation are limited and the long-term effectiveness remains to be determined, especially in dark-skinned populations. METHODS: Medical records of BD patients who received ALA-PDT with red light irradiation between February 2011 and June 2021 were reviewed and summarized...
April 20, 2024: Clinical and Experimental Dermatology
#10
JOURNAL ARTICLE
Hannah Lawson, James P Holt-Martyn, Vilma Dembitz, Yuka Kabayama, Lydia M Wang, Aarushi Bellani, Samanpreet Atwal, Nadia Saffoon, Jozef Durko, Louie N van de Lagemaat, Azzura L De Pace, Anthony Tumber, Thomas Corner, Eidarus Salah, Christine Arndt, Lennart Brewitz, Matthew Bowen, Louis Dubusse, Derek George, Lewis Allen, Amelie V Guitart, Tsz Kan Fung, Chi Wai Eric So, Juerg Schwaller, Paolo Gallipoli, Donal O'Carroll, Christopher J Schofield, Kamil R Kranc
Acute myeloid leukemia (AML) is a largely incurable disease, for which new treatments are urgently needed. While leukemogenesis occurs in the hypoxic bone marrow, the therapeutic tractability of the hypoxia-inducible factor (HIF) system remains undefined. Given that inactivation of HIF-1α/HIF-2α promotes AML, a possible clinical strategy is to target the HIF-prolyl hydroxylases (PHDs), which promote HIF-1α/HIF-2α degradation. Here, we reveal that genetic inactivation of Phd1/Phd2 hinders AML initiation and progression, without impacting normal hematopoiesis...
April 18, 2024: Nature Cancer
#11
JOURNAL ARTICLE
Yu Wang, Bowen Li, Juankun Liao, Yan Wang
OBJECTIVES: To compare the changes in condylar position after mandibular reconstruction with free fibular flap(FFF) and the differences between computer-assisted techniques and traditional methods on CT images. METHODS: Thirty-four patients who underwent mandibular reconstruction with free fibular flap were selected according to the inclusion and exclusion criteria. In the 3D group, virtual surgical planning (VSP) with osteotomy cutting plate and placement guiding plate were used, while the traditional group underwent freehand reconstruction...
April 15, 2024: BMC Oral Health
#12
JOURNAL ARTICLE
Benjamin Djulbegovic, Alice Boylan, Shelby J Kolo, Danielle Bowen Scheurer, Sydney Anuskiewicz, Flora Khaledi, Kimberley Youkhana, Sarah Madgwick, Neema Maharjan, Iztok Hozo
Current hospital VTE (venous thromboembolism) prophylaxis for medical patients has been characterized by both underuse and, increasingly, overuse. The American Society of Hematology (ASH) has endorsed the use of risk assessment models (RAM) as an approach to individualize VTE prophylaxis as a way of balancing overuse (excessive risk of bleeding) and underuse (risk of avoidable VTE). ASH has endorsed IMPROVE (International Medical Prevention Registry on Venous Thromboembolism) risk assessment models - the only RAM to assess short-term bleeding and VTE risk in acutely ill medical inpatients...
April 15, 2024: Blood Advances
#13
JOURNAL ARTICLE
Xiqian Zhou, Junyong Zhao, Tao Yan, Danrong Ye, Yuying Wang, Bai'an Zhou, Diya Liu, Xuehui Wang, Wenfang Zheng, Bowen Zheng, Fengyuan Qian, Yating Li, Dengfeng Li, Lin Fang
Breast cancer has the highest global incidence and mortality rates among all cancer types. Abnormal expression of the Annexin family has been observed in different malignant tumors, including upregulated ANXA9 in breast cancer. We found highly expressed ANXA9 in metastatic breast cancer tissues, which is correlated with breast cancer progression. In vitro, the functional experiments indicated ANXA9 influenced breast cancer proliferation, motility, invasion, and apoptosis; in vivo, downregulation of ANXA9 suppressed breast cancer xenograft tumor growth and lung metastasis...
April 12, 2024: Cell Death & Disease
#14
JOURNAL ARTICLE
Sowmya Mekala, Ravi Rai, Samantha Loretta Reed, Bill Bowen, George K Michalopoulos, Joseph Locker, Reben Raeman, Michael Oertel
BACKGROUND/AIM: Activin A is involved in the pathogenesis of human liver diseases, but its therapeutic targeting is not fully explored. Here, we tested the effect of novel, highly specific small-molecule-based activin A antagonists (NUCC-474/555) in improving liver regeneration following partial hepatectomy and halting fibrosis progression in models of chronic liver diseases (CLDs). METHODS: Cell toxicity of antagonists was determined in rat hepatocytes and Huh-7 cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay...
April 8, 2024: Cells
#15
JOURNAL ARTICLE
Haoran Zhong, Bowen Dong, Danlin Zhu, Zhiqiang Fu, Jinming Liu, Yamei Jin
Schistosomiasis is a fatal zoonotic parasitic disease that also threatens human health. The main pathological features of schistosomiasis are granulomatous inflammation and subsequent liver fibrosis, which is a complex, chronic, and progressive disease. Extracellular vesicles (EVs) derived from schistosome eggs are broadly involved in host-parasite communication and act as important contributors to schistosome-induced liver fibrosis. However, it remains unclear whether substances secreted by the EVs of Schistosoma japonicum, a long-term parasitic "partner" in the hepatic portal vein of the host, also participate in liver fibrosis...
April 10, 2024: PLoS Pathogens
#16
JOURNAL ARTICLE
Kai Zhang, Jianguo Chen, Bowen Chen, Yu Han, Tianyi Cai, JiaYu Zhao, ZhaoXuan Gu, Min Gao, Zhengyan Hou, Xiaoqi Yu, FangMing Gu, Yafang Gao, Rui Hu, Jinyu Xie, Tianzhou Liu, Dan Cui, Bo Li
BACKGROUND: Prior studies have established a connection between folate intake and cardiovascular disease (CVD). Abdominal aortic calcification (AAC) has been introduced as a good predictor of CVD events, but no previous study has investigated the relationship between dietary folate intake and severe AAC. Therefore, the study aims to explore the association between dietary folate intake and severe AAC in the United States (US) middle-aged and elderly population. METHODS: This study employed cross-sectional data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) to examine the relationship between dietary folate intake and severe AAC...
2024: Diabetes & Vascular Disease Research
#17
JOURNAL ARTICLE
Bowen Li, Xiangbin Meng, Chao Fu, Zhihao Yang, Xin Zhao
OBJECTIVE: This study utilized computed tomography angiography (CTA) to assess the risk of acute type A aortic dissection (ATAAD) by analyzing the imaging morphology indicators of the ascending aorta, along with the relevant risk factors associated with aortic dissection. METHODS: The study utilized a retrospective observational research design. The population consisted of 172 patients who received treatment in the Department of Cardiothoracic Surgery at Qilu Hospital, Shandong University, from January 2018 to December 2022...
2024: Frontiers in Cardiovascular Medicine
#18
REVIEW
Bowen Dai, Wangquan Ji, Peiyu Zhu, Shujie Han, Yu Chen, Yuefei Jin
OBJECTIVE: To reduce the incidence of severe illness and fatalities, and promote the awareness of protection and precaution, increased vaccination, strengthen the physical fitness, frequent ventilation, and health education should be enhanced among vulnerable populations as essential measures for the future control of COVID-19. STUDY DESIGN: Systematic review. METHOD: The search was done using PubMed, EMBASE and Web of Science for studies without language restrictions, published up through March 2023, since their authoritative and comprehensive literature search database...
June 2024: Public health in practice
#19
JOURNAL ARTICLE
Jingyan Zhu, Qiuyan Jiang, Shaoyan Gao, Qin Xia, Huizhe Zhang, Bowen Liu, Ruixi Zhao, Haixia Jiang, Xiaohe Li, Aiguo Xu, Honggang Zhou, Zuojun Xu, Cheng Yang
Idiopathic pulmonary fibrosis (IPF) is one of the most fatal chronic interstitial lung diseases with unknown pathogenesis, current treatments cannot truly reverse the progression of the disease. Pulmonary macrophages, especially bone marrow derived pro-fibrotic macrophages, secrete multiple kinds of profibrotic mediators (SPP1, CD206, CD163, IL-10, CCL18…), thus further promote myofibroblast activation and fibrosis procession. IL20Rb is a cell-surface receptor that belongs to IL-20 family. The role of IL20Rb in macrophage activation and pulmonary fibrosis remains unclear...
April 5, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
#20
JOURNAL ARTICLE
Bowen Liu, Qiuyan Jiang, Ruxuan Chen, Huizhe Zhang, Qin Xia, Chi Shao, Xiangning Liu, Mengqi Wang, Yujie Shi, Jingyan Zhu, Ruixi Zhao, Haixia Jiang, Shaoyan Gao, Xiaohe Li, Honggang Zhou, Cheng Yang, Hui Huang
Idiopathic pulmonary fibrosis (IPF) is a heterogeneous group of lung diseases with different etiologies and characterized by progressive fibrosis. This disease usually causes pulmonary structural remodeling and decreased pulmonary function. The median survival of IPF patients is 2-5 years. Predominantly accumulation of type II innate immune cells accelerates fibrosis progression by secreting multiple pro-fibrotic cytokines. Group 2 innate lymphoid cells (ILC2) and monocytes/macrophages play key roles in innate immunity and aggravate the formation of pro-fibrotic environment...
April 4, 2024: International Immunopharmacology
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