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REVIEW
Clémence Queffélec, Palas Baran Pati, Yann Pellegrin
1,10-Phenanthroline (phen) is one of the most popular ligands ever used in coordination chemistry due to its strong affinity for a wide range of metals with various oxidation states. Its polyaromatic structure provides robustness and rigidity, leading to intriguing features in numerous fields (luminescent coordination scaffolds, catalysis, supramolecular chemistry, sensors, theranostics, etc.). Importantly, phen offers eight distinct positions for functional groups to be attached, showcasing remarkable versatility for such a simple ligand...
May 15, 2024: Chemical Reviews
#22
JOURNAL ARTICLE
Jaclyn M Martindale, Victor M Ringheanu, Kelly A Pring, Sandra Norona, Kimberly Wiseman, Roy E Strowd, Leah Chapman, Joseph Rigdon, Stephen R Rapp, Eric A Storch, Edward Ip, Jonathan W Mink
INTRODUCTION: Persistent Tic Disorders such as Tourette Syndrome are common neurodevelopmental disorders that are highly stigmatized. Many individuals with Persistent Tic Disorders experience peer rejection, loneliness, and self-stigma. Experiencing stigmatization during childhood can influence the persistence of moderate-to-severe tics later in life. Additionally, these factors have been associated with increased suicidal ideation, suicide attempts, and psychiatric symptom severity. There is a need for interventions to reduce stigma and stigmatization in Persistent Tic Disorders...
2024: Frontiers in Psychology
#23
Santiago Peralta, William Katt, Cheryl Balkman, Scott Butler, Patrick Carney, Amy Todd-Donato, Matthew Drozd, Gerald Duhamel, Nadine Fiani, Jordan Ford, Jennifer Grenier, Jessica Hayward, Kristiina Heikinheimo, Kelly Hume, Elizabeth Moore, Rishi Puri, Skylar Sylvester, Sydney Warshaw, Suzin Webb, Andrew White, Alexandra Wright, Richard Cerione
Oral tumors are relatively common in dogs, and canine oral squamous cell carcinoma (COSCC) is the most prevalent oral malignancy of epithelial origin. COSCC is locally aggressive with up to 20% of patients showing regional or distant metastasis at the time of diagnosis. The treatment of choice most typically involves wide surgical excision. Although long-term remission is possible, treatments are associated with significant morbidity and can negatively impact functionality and quality of life. OSCCs have significant upregulation of the RAS-RAF-MEK-MAPK signaling axis, and we had previously hypothesized that small-molecule inhibitors that target RAS signaling might effectively inhibit tumor growth and progression...
May 2, 2024: Research Square
#24
Martin Hunt, Angie S Hinrichs, Daniel Anderson, Lily Karim, Bethany L Dearlove, Jeff Knaggs, Bede Constantinides, Philip W Fowler, Gillian Rodger, Teresa Street, Sheila Lumley, Hermione Webster, Theo Sanderson, Christopher Ruis, Nicola de Maio, Lucas N Amenga-Etego, Dominic S Y Amuzu, Martin Avaro, Gordon A Awandare, Reuben Ayivor-Djanie, Matthew Bashton, Elizabeth M Batty, Yaw Bediako, Denise De Belder, Estefania Benedetti, Andreas Bergthaler, Stefan A Boers, Josefina Campos, Rosina Afua Ampomah Carr, Facundo Cuba, Maria Elena Dattero, Wanwisa Dejnirattisai, Alexander Dilthey, Kwabena Obeng Duedu, Lukas Endler, Ilka Engelmann, Ngiambudulu M Francisco, Jonas Fuchs, Etienne Z Gnimpieba, Soraya Groc, Jones Gyamfi, Dennis Heemskerk, Torsten Houwaart, Nei-Yuan Hsiao, Matthew Huska, Martin Hölzer, Arash Iranzadeh, Hanna Jarva, Chandima Jeewandara, Bani Jolly, Rageema Joseph, Ravi Kant, Karrie Ko Kwan Ki, Satu Kurkela, Maija Lappalainen, Marie Lataretu, Chang Liu, Gathsaurie Neelika Malavige, Tapfumanei Mashe, Juthathip Mongkolsapaya, Brigitte Montes, Jose Arturo Molina Mora, Collins M Morang'a, Bernard Mvula, Niranjan Nagarajan, Andrew Nelson, Joyce M Ngoi, Joana Paula da Paixão, Marcus Panning, Tomas Poklepovich, Peter K Quashie, Diyanath Ranasinghe, Mara Russo, James Emmanuel San, Nicholas D Sanderson, Vinod Scaria, Gavin Screaton, Tarja Sironen, Abay Sisay, Darren Smith, Teemu Smura, Piyada Supasa, Chayaporn Suphavilai, Jeremy Swann, Houriiyah Tegally, Bryan Tegomoh, Olli Vapalahti, Andreas Walker, Robert J Wilkinson, Carolyn Williamson, Tulio de Oliveira, Timothy Ea Peto, Derrick Crook, Russell Corbett-Detig, Zamin Iqbal
The SARS-CoV-2 genome occupies a unique place in infection biology - it is the most highly sequenced genome on earth (making up over 20% of public sequencing datasets) with fine scale information on sampling date and geography, and has been subject to unprecedented intense analysis. As a result, these phylogenetic data are an incredibly valuable resource for science and public health. However, the vast majority of the data was sequenced by tiling amplicons across the full genome, with amplicon schemes that changed over the pandemic as mutations in the viral genome interacted with primer binding sites...
April 30, 2024: bioRxiv
#25
JOURNAL ARTICLE
Charles J Creech, Jasmine M Hope, Anastasia Zarkou, Edelle C Field-Fote
Considering the growing interest in clinical applications of neuromodulation, assessing effects of various modulatory approaches is increasingly important. Monosynaptic spinal reflexes undergo depression following repeated activation, offering a means to quantify neuromodulatory influences. Following spinal cord injury (SCI), changes in reflex modulation are associated with spasticity and impaired motor control. To assess disrupted reflex modulation, low-frequency depression (LFD) of Hoffman (H)-reflex excitability is examined, wherein the amplitudes of conditioned reflexes are compared to an unconditioned control reflex...
2024: PloS One
#26
JOURNAL ARTICLE
Md Alamin, Most Humaira Sultana, Isaac Adeyemi Babarinde, A K M Azad, Mohammad Ali Moni, Haiming Xu
The complicated process of neuronal development is initiated early in life, with the genetic mechanisms governing this process yet to be fully elucidated. Single-cell RNA sequencing (scRNA-seq) is a potent instrument for pinpointing biomarkers that exhibit differential expression across various cell types and developmental stages. By employing scRNA-seq on human embryonic stem cells, we aim to identify differentially expressed genes (DEGs) crucial for early-stage neuronal development. Our focus extends beyond simply identifying DEGs...
March 27, 2024: Briefings in Bioinformatics
#27
JOURNAL ARTICLE
Stuart J Hope, Sendhil Govender, Rachel L Taylor, Belinda Y C Kwok, Jacob M Pogson, Benjamin Nham, Chao Wang, Allison S Young, Alyssa C Dyball, Jonathan H K Kong, Miriam S Welgampola, Sally M Rosengren
OBJECTIVE: To examine the origin of cervical vestibular evoked myogenic potential (cVEMP) late waves (n34-p44) elicited with air-conducted click stimuli. DESIGN: Using a retrospective design, cVEMPs from normal volunteers were compared to those obtained from patients with vestibular and auditory pathologies. STUDY SAMPLE: (1) Normal volunteers (n = 56); (2) severe-to-profound sensorineural hearing loss (SNHL) with normal vestibular function (n = 21); (3) peripheral vestibular impairment with preserved hearing (n = 16); (4) total vestibulocochlear deficit (n = 23)...
May 13, 2024: International Journal of Audiology
#28
REVIEW
Ruizhe Chen, Hao Wang
Time-to-event endpoints are widely used as measures of patients' well-being and indicators of prognosis. In imaging-based biomarker studies, there are increasingly more studies that focus on examining imaging biomarkers' prognostic or predictive utilities on those endpoints, whether in a trial or an observational study setting. In this educational review article, we briefly introduce some basic concepts of time-to-event endpoints and point out potential pitfalls in the context of imaging biomarker research in hope of improving radiologists' understanding of related subjects...
May 13, 2024: Journal of Magnetic Resonance Imaging: JMRI
#29
REVIEW
Ammir Y Helou, Jackson C Bittencourt
Over several decades, motivated behavior has emerged as a crucial study area within neuroscience. Understanding the neural substrates and mechanisms driving behaviors related to reward, addiction, and other motivation forms is pivotal for novel therapeutic interventions. This review provides a bibliometric analysis of the literature, highlighting the main trends, influential authors, and the potential future direction of the field. Utilizing a dataset comprised by 3,150 publications from the Web of Science and Scopus databases ("motivated behavior as query), we delve into key metrics like publication trends, keyword prevalence, author collaborations, citation impacts, and employed an unsupervised natural language processing technique - Latent Dirichlet Allocation - for topic modeling...
2024: Frontiers in Behavioral Neuroscience
#30
Manuela Montatore, Federica Masino, Gianmichele Muscatella, Rossella Gifuni, Giacomo Fascia, Alessio Sciacqua, Giuseppe Guglielmi
We report a case of myxofibrosarcoma of the posterior region of the femur, part of the group of soft-tissue sarcomas: a set of rare and heterogeneous tumors with various subtypes and different prognostic. It is characterized by local infiltrative activity and an extremely high rate of local recurrence. A 58-year-old man came to the Radiology Department to examine a voluminous round and expansive formation of the posterior thigh region. The patient stated that the mass had grown suddenly for about 3 months, maybe after a trauma, increasing in volume exponentially and causing him discomfort, embarrassment, and pain...
August 2024: Radiology Case Reports
#31
JOURNAL ARTICLE
Siyi Zhang, Yue Zhou, Jinghui Wang, Qingan Fu, Tianzhou Shen, Guanrui Pan, Renfei Luo, Xinlei Yang, Long Jiang, Hui Hu
BACKGROUND: Lipoprotein(a) [Lp(a)] is a well-established risk factor for ischaemic stroke (IS). It is unclear whether Lp(a) is associated with IS in patients with atrial fibrillation (AF). The aim of this study is to explore the association between the concentration of Lp(a) and the risk of IS in AF patients, hope to find the potential risk factor for the IS in AF patients. METHODS: This study is a retrospective cohort study. The screened AF patients between January 2017 and July 2021 were matched at 1:1 by the propensity score matching (PSM) method in the Second Affiliated Hospital of Nanchang University...
2024: International Journal of General Medicine
#32
JOURNAL ARTICLE
Yanhua Wang, Manyi Xu, Ke Wang, Yue Hao, Chunwei Xu, Zhengbo Song
BACKGROUND: While targeted therapy has become the standard treatment for certain non-small-cell lung cancer (NSCLC) patients with gene mutation positivity, there remains a lack of enough reports of the efficacy of mesenchymal-epithelial transition (MET) alterations in the real world. OBJECTIVES: We aimed to explore the efficacy and toxicity of targeted therapy in NSCLC patients with different types of MET alterations and hope to provide more clinical medication guidance...
2024: Therapeutic Advances in Medical Oncology
#33
JOURNAL ARTICLE
Xun Wang, Xin Wang, Bengang Hui, Jingsheng Cai, Heng Zhao, Bowei Qiao, Jiangnan Duan, Kezhong Chen, Jun Wang, Jie Lei, Fan Yang
BACKGROUND: Resectable non-small cell lung cancer (NSCLC) patients have a high risk of recurrence. Multiple randomized controlled trials (RCTs) have shown that neoadjuvant chemo-immunotherapy brings new hope for these patients. The study aims to evaluate the safety, surgery-related outcomes and oncological outcomes for neoadjuvant chemo-immunotherapy in real-world setting with a large sample size and long-term follow-up. METHODS: Patients with clinical stage IB-IIIB NSCLC who received neoadjuvant chemo-immunotherapy at two Chinese institutions were included in this retrospective cohort study...
April 29, 2024: Translational Lung Cancer Research
#34
JOURNAL ARTICLE
Kristina Zalud, Griffin Collins, Justin N Baker, Jennifer W Mack, Erica C Kaye
PURPOSE: For children with advanced cancer and their families, communication about prognosis is critical. Unfortunately, data demonstrate that prognostic communication occurs infrequently and inconsistently across advancing illness. Prior to developing an intervention to improve prognostic communication, we aimed to (1) characterize parent and oncologist perspectives on "best" approaches for prognostic communication, and (2) explore similarities and differences between parent and oncologist perspectives...
May 13, 2024: Supportive Care in Cancer
#35
JOURNAL ARTICLE
William Burton-Fisher, Kim Gordon
PURPOSE: Long COVID is a global health concern which has debilitating effects on the individual experiencing it. In the United Kingdom, psychological therapies are being offered to people with long COVID, although the evidence for these therapies is yet to be demonstrated. This research aimed to understand how therapists and clients define and understand recovery from long COVID, and use hope theory to interpret the results. METHODS: An online Q-methodology was employed, where participants sorted a range of statements pertaining to long COVID recovery based on their level of agreement with them...
May 12, 2024: British Journal of Health Psychology
#36
JOURNAL ARTICLE
Lei Li, Lan Zhu
• Endometrial hyperplasia can be classified as either hyperplasia without atypia or atypical hyperplasia. • Abnormal uterine bleeding is the most common symptom of endometrial hyperplasia. Transvaginal ultrasound is recommended for initial imaging to evaluate endometrial hyperplasia (evidence level 2+), while transrectal ultrasound is recommended for virgo patients (evidence level 3). • Endometrial biopsy should be used to confirm diagnosis in patients where endometrial lesions are suspected...
May 9, 2024: European Journal of Surgical Oncology
#37
Sarah Fogarty, Alexander E P Heazell, Niki Munk, Phillipa Hay
No abstract text is available yet for this article.
May 11, 2024: Pilot and Feasibility Studies
#38
REVIEW
Yaron Avitzur, Lissette Jimenez, Inez Martincevic, Sari Acra, Glenda Courtney-Martin, Megan Gray, Kayla Hope, Aleixo Muise, Paula M Prieto Jimenez, Nancy Taylor, Jay R Thiagarajah, Martín G Martín
Congenital diarrheas and enteropathies (CODE) are a group of rare, heterogenous, monogenic disorders that lead to chronic diarrhea in infancy. Definitive treatment is rarely available, and supportive treatment is the mainstay. Nutritional management in the form of either specialized formulas, restrictive diet, or parenteral nutrition support in CODE with poor enteral tolerance, is the cornerstone of CODE treatment and long-term growth. The evidence to support the use of specific diet regimens and nutritional approaches in most CODE disorders is limited due to the rarity of those diseases and the scant published clinical experience...
May 9, 2024: American Journal of Clinical Nutrition
#39
JOURNAL ARTICLE
Yuanzhi Yang, Yang Zheng, Zhong Chen, Cenglin Xu
No abstract text is available yet for this article.
May 11, 2024: Neuroscience Bulletin
#40
JOURNAL ARTICLE
Chunlan Zhang, Ruxin Tan, Xiaoqing Zhou, Ruru Wang, Xin Wang, Ren Ma, Fangxuan Chu, Ying Li, Tao Yin, Zhipeng Liu
Transcranial magneto-acoustic stimulation (TMAS), which is characterized by high spatiotemporal resolution and high penetrability, is a non-invasive neuromodulation technology based on the magnetic-acoustic coupling effect. To reveal the effects of TMAS treatment on amyloid-beta (Aβ) plaque and synaptic plasticity in Alzheimer's disease, we conducted a comparative analysis of TMAS and transcranial ultrasound stimulation (TUS) based on acoustic effects in 5xFAD mice and BV2 microglia cells. We found that the TMAS-TUS treatment effectively reduced amyloid plaque loads and plaque-associated neurotoxicity...
April 24, 2024: International Journal of Molecular Sciences
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