Tina Chou, Brian J Kochanowski, Ashley Hayden, Benjamin M Borron, Miguel C Barbeiro, Junqian Xu, Joo-Won Kim, Xuefeng Zhang, Richard R Bouchard, Kinh Luan Phan, Wayne K Goodman, Darin D Dougherty
OBJECTIVES: Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is effective for treatment-resistant obsessive-compulsive disorder (OCD); however, DBS is associated with neurosurgical risks. Transcranial focused ultrasound (tFUS) is a newer form of noninvasive (ie, nonsurgical) stimulation that can modulate deeper regions, such as the VC/VS. tFUS parameters have just begun to be studied and have often not been compared in the same participants. We explored the effects of three VC/VS tFUS protocols and an entorhinal cortex (ErC) tFUS session on the VC/VS and cortico-striato-thalamo-cortical circuit (CSTC) in healthy individuals for later application to patients with OCD...
April 29, 2024: Neuromodulation: Journal of the International Neuromodulation Society