Gema Frühbeck, Javier Gómez-Ambrosi, Beatriz Ramírez, Sara Becerril, Amaia Rodríguez, Amaia Mentxaka, Víctor Valentí, Rafael Moncada, Gabriel Reina, Jorge Baixauli, Marcos Casado, Camilo Silva, Javier Escalada, Victoria Catalán
BACKGROUND: Obesity-associated dysfunctional intestinal permeability contributes to systemic chronic inflammation leading to the development of metabolic diseases. The inflammasomes constitute essential components in the regulation of intestinal homeostasis. We aimed to determine the impact of the inflammasomes in the regulation of gut barrier dysfunction and metabolic inflammation in the context of obesity and type 2 diabetes (T2D). METHODS: Blood samples obtained from 80 volunteers (n = 20 normal weight, n = 21 OB without T2D, n = 39 OB with T2D) and a subgroup of jejunum samples were used in a case-control study...
February 5, 2024: Cellular and Molecular Life Sciences: CMLS