Nataliia P Antonova, Daria V Vasina, Igor V Grigoriev, Evgeny V Usachev, Andrey V Aleshkin, Aleksei M Vorobev, Aleksei I Laishevtsev, Andrey V Kapustin, Vasiliy A Savinov, Mariia N Anurova, Anastasia A Zackharova, Timofey A Remizov, Valentine V Makarov, Sergey M Yudin, Vladimir A Gushchin
Antibacterial therapy with phage-encoded endolysins or their modified derivatives with improved antibacterial, biochemical and pharmacokinetic properties is one of the most promising strategies that can supply existing antibacterial drugs array. Gram-negative bacteria-induced infections treatment is especially challenging because of rapidly spreading bacterial resistance. We have developed modified endolysin LysECD7-SMAP with a significant antibacterial activity and broad spectra of action against gram-negative bacteria...
April 29, 2024: Journal of Pharmaceutical Sciences