Yujia Yuan, Longhui Yuan, Jingchao Yang, Fei Liu, Shuyun Liu, Lan Li, Guangneng Liao, Xi Tang, Jingqiu Cheng, Jingping Liu, Younan Chen, Yanrong Lu
Macrophages (Mφ) autophagy is a pivotal contributor to inflammation-related diseases. However, the mechanistic details of its direct role in acute kidney injury (AKI) were unclear. Here, we show that Mφ promote AKI progression via crosstalk with tubular epithelial cells (TECs), and autophagy of Mφ was activated and then inhibited in cisplatin-induced AKI mice. Mφ-specific depletion of ATG7 (Atg7Δmye ) aggravated kidney injury in AKI mice, which was associated with tubulointerstitial inflammation...
May 23, 2024: Nature Communications