Minrong Wang, Feng Zhang, Xuemei Ning, Chan Wu, Yue Zhou, Zhixian Gou, Yang Fan, Rongrong Duan, Zhongni Li, Chunyan Shao, Liqun Lu
Nuclear factor e2-related factor 2 (Nrf2) plays a key role in cellular resistance to oxidative stress injury. Oxidative stress injury, caused by Nrf2 imbalance, results in increased pyroptosis, DNA damage, and inflammatory activation, which may lead to the arrest of alveolar development and bronchopulmonary dysplasia (BPD) in premature infants under hyperoxic conditions. We established a BPD mouse model to investigate the effects of tert-butylhydroquinone (TBHQ), an Nrf2 activator, on oxidative stress injury, pyroptosis, NLRP3 inflammasome activation, and alveolar development...
August 9, 2023: Inflammation