Ryuichi Takenaka, Shigekiyo Matsumoto, Shinichi Nureki, Shinsuke Wada, Yoshimasa Oyama, Teruo Sakamoto, Takaaki Kitano, Osamu Shigemitsu
BACKGROUND: In critically ill patients, healthy vitamin C levels are important to avoid an imbalance in reactive oxygen species. To achieve this, oxidative stress levels in emergency patients need to be accurately measured in real-time. However, normally, reactive oxygen/nitrogen species are short-lived, rendering measurement difficult; moreover, measurement of relatively stable antioxidants and other oxidative stress markers in real-time is challenging. Therefore, we used electron-spin resonance spectrometry (ESR) to assess vitamin C levels, clarify their relationship with patients' severity, and establish more effective vitamin C therapy in critically ill patients...
August 5, 2023: BMC Emergency Medicine