Hugh Adler, Esther L German, Elena Mitsi, Elissavet Nikolaou, Sherin Pojar, Caz Hales, Rachel Robinson, Victoria Connor, Helen Hill, Angela D Hyder-Wright, Lepa Lazarova, Catherine Lowe, Emma L Smith, India Wheeler, Seher R Zaidi, Simon P Jochems, Dessi Loukov, Jesús Reiné, Carla Solórzano-Gonzalez, Polly de Gorguette d'Argoeuves, Tessa Jones, David Goldblatt, Tao Chen, Stephen J Aston, Neil French, Andrea M Collins, Stephen B Gordon, Daniela M Ferreira, Jamie Rylance
RATIONALE: Pneumococcal colonisation is key to the pathogenesis of invasive disease, but is also immunogenic in young adults, protecting against re-colonisation. Colonisation is rarely detected in older adults, despite high rates of pneumococcal disease. OBJECTIVES: To establish experimental human pneumococcal colonisation in healthy adults aged 50-84 years, to measure the immune response to pneumococcal challenge, and to assess the protective effect of prior colonisation against autologous strain rechallenge...
September 17, 2020: American Journal of Respiratory and Critical Care Medicine