Dingase Dula, Ben Morton, Tarsizio Chikaonda, Anthony E Chirwa, Edna Nsomba, Vitumbiko Nkhoma, Clara Ngoliwa, Simon Sichone, Bridgette Galafa, Godwin Tembo, Mphatso Chaponda, Neema Toto, Raphael Kamng'ona, Lumbani Makhaza, Alfred Muyaya, Faith Thole, Evaristar Kudowa, Ashleigh Howard, Tinashe Kenny-Nyazika, John Ndaferankhande, Christopher Mkandawire, Gift Chiwala, Lorensio Chimgoneko, Ndaziona P K Banda, Jamie Rylance, Daniela Ferreira, Kondwani Jambo, Marc Y R Henrion, Stephen B Gordon
BACKGROUND: The effect of childhood pneumococcal conjugate vaccine implementation in Malawi is threatened by absence of herd effect. There is persistent vaccine-type pneumococcal carriage in both vaccinated children and the wider community. We aimed to use a human infection study to measure 13-valent pneumococcal conjugate vaccine (PCV13) efficacy against pneumococcal carriage. METHODS: We did a double-blind, parallel-arm, randomised controlled trial investigating the efficacy of PCV13 or placebo against experimental pneumococcal carriage of Streptococcus pneumoniae serotype 6B (strain BHN418) among healthy adults (aged 18-40 years) from Blantyre, Malawi...
September 2023: The Lancet. Microbe