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JOURNAL ARTICLE
Xu-Cheng He, Mario Simon, Siddharth Iyer, Hong-Bin Xie, Birte Rörup, Jiali Shen, Henning Finkenzeller, Dominik Stolzenburg, Rongjie Zhang, Andrea Baccarini, Yee Jun Tham, Mingyi Wang, Stavros Amanatidis, Ana A Piedehierro, Antonio Amorim, Rima Baalbaki, Zoé Brasseur, Lucía Caudillo, Biwu Chu, Lubna Dada, Jonathan Duplissy, Imad El Haddad, Richard C Flagan, Manuel Granzin, Armin Hansel, Martin Heinritzi, Victoria Hofbauer, Tuija Jokinen, Deniz Kemppainen, Weimeng Kong, Jordan Krechmer, Andreas Kürten, Houssni Lamkaddam, Brandon Lopez, Fangfang Ma, Naser G A Mahfouz, Vladimir Makhmutov, Hanna E Manninen, Guillaume Marie, Ruby Marten, Dario Massabò, Roy L Mauldin, Bernhard Mentler, Antti Onnela, Tuukka Petäjä, Joschka Pfeifer, Maxim Philippov, Ananth Ranjithkumar, Matti P Rissanen, Siegfried Schobesberger, Wiebke Scholz, Benjamin Schulze, Mihnea Surdu, Roseline C Thakur, António Tomé, Andrea C Wagner, Dongyu Wang, Yonghong Wang, Stefan K Weber, André Welti, Paul M Winkler, Marcel Zauner-Wieczorek, Urs Baltensperger, Joachim Curtius, Theo Kurtén, Douglas R Worsnop, Rainer Volkamer, Katrianne Lehtipalo, Jasper Kirkby, Neil M Donahue, Mikko Sipilä, Markku Kulmala
The main nucleating vapor in the atmosphere is thought to be sulfuric acid (H2 SO4 ), stabilized by ammonia (NH3 ). However, in marine and polar regions, NH3 is generally low, and H2 SO4 is frequently found together with iodine oxoacids [HIO x , i.e., iodic acid (HIO3 ) and iodous acid (HIO2 )]. In experiments performed with the CERN CLOUD (Cosmics Leaving OUtdoor Droplets) chamber, we investigated the interplay of H2 SO4 and HIO x during atmospheric particle nucleation. We found that HIO x greatly enhances H2 SO4 (-NH3 ) nucleation through two different interactions...
December 15, 2023: Science
#22
JOURNAL ARTICLE
Fangzhi Yue, Ying Shi, Shanyu Wu, Lin Xing, Dan He, Lin Wei, Anqi Qiu, Ryan Russell, Dongmei Zhang
Metformin prevents progression of non-alcoholic fatty liver disease (NAFLD). However, the potential mechanism is not entirely understood. Ferroptosis, a recently recognized nonapoptotic form of regulated cell death, has been reported to be involved in the pathogenesis of NAFLD. Here, we investigated the effects of metformin on ferroptosis and its potential mechanism in NAFLD. We found that metformin prevented the progression of NAFLD, and alleviated hepatic iron overload (HIO), ferroptosis and upregulated ferroportin (FPN) expression in vivo and in vitro ...
December 15, 2023: IScience
#23
JOURNAL ARTICLE
Hio Kuan Wu, Guanhui Chen, Zhengchuan Zhang, Xiaoxuan Lin, Xiaoqiong Huang, Feilong Deng, Yiming Li
OBJECTIVES: To examine the effect of artificial landmarks of prefabricated auxiliary devices (PAD) located at different arch positions on the accuracy of complete-arch edentulous digital implant scanning. METHODS: A reference model containing four analogs and PAD were fabricated by a 3D printer (AccuFab-C1s, 3DShining). 10 digital scans were performed using an intraoral scanner (Aoralscan 3, 3DShining), sv 1.0.0.3115, with artificial landmarks located at different arch positions: group I, without any artificial landmarks; group II, with artificial landmarks at the anterior region; group III, with artificial landmarks at the posterior region...
December 8, 2023: Journal of Dentistry
#24
JOURNAL ARTICLE
Kentaro Okada, Jumpei Yokota, Tomoki Yamashita, Tatsuya Inui, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi
Human intestinal organoids (HIOs) have been reported to exert their functions in a way that mimics living organs, and HIOs-derived monolayers are expected to be applied to in vitro intestinal pharmacokinetic studies. However, HIOs are established from human tissue, which raises issues of availability and ethics. In the present study, to solve these problems, we have established intestinal organoids using commercially available cryopreserved human intestinal epithelial cells (C-IOs), and compared their functions with biopsy-derived human intestinal organoids (B-IOs) from a pharmacokinetic point of view...
October 8, 2023: Drug Metabolism and Pharmacokinetics
#25
JOURNAL ARTICLE
Chi-Chong Chio, Hio-Wai Chan, Shih-Hsiang Chen, Hsing-I Huang
Enterovirus D68 (EV-D68) primarily spreads through the respiratory tract and causes respiratory symptoms in children and acute flaccid myelitis (AFM). Type III interferons (IFNs) play a critical role in inhibiting viral growth in respiratory epithelial cells. However, the mechanism by which EV-D68 induces type III IFN production is not yet fully understood. In this study, we show that EV-D68 infection stimulates Calu-3 cells to secrete IFN-λ. The transfection of EV-D68 viral RNA (vRNA) stimulated IFN-λ via MDA5...
November 29, 2023: Virus Research
#26
JOURNAL ARTICLE
Cameron Benner, Jonathan Jui, Matthew R Neth, Ritu Sahni, Kathryn Thompson, Jeffrey Smith, Craig Newgard, Mohamud R Daya, Joshua R Lupton
BACKGROUND: The optimal initial vascular access strategy for out-of-hospital cardiac arrest (OHCA) remains unknown. Our objective was to evaluate the association between peripheral intravenous (PIV), tibial intraosseous (TIO), or humeral intraosseous (HIO) as first vascular attempt strategies and outcomes for patients suffering OHCA. METHOD: This was a secondary analysis of the Portland Cardiac Arrest Epidemiologic Registry, which included adult patients (≥18 years-old) with EMS-treated, non-traumatic OHCA from 2018-2021...
November 28, 2023: Prehospital Emergency Care
#27
JOURNAL ARTICLE
Hio Kuan Wu, Guanhui Chen, Jing Wang, Zhengchuan Zhang, Xiaoqiong Huang, Xiaoxuan Lin, Feilong Deng, Yiming Li
OBJECTIVES: This study aimed to evaluate the impact of prefabricated auxiliary devices (PAD) and scanning patterns on the accuracy of complete-arch implant digital impressions. METHODS: An edentulous maxillary model was inserted with four parallel implant analogs and four PAD. The model was scanned with D2000 dental laboratory scanner as the reference scans. Test scans were obtained by 8 scanning patterns (Scanning Pattern A - G, SP A - G) with (test group) or without (control group) using the PAD by an intraoral scanner (Aoralscan 3, 3DShining)...
November 20, 2023: Journal of Dentistry
#28
REVIEW
Adriana Mulero-Russe, Andrés J García
Human intestinal organoids (HIOs) derived from pluripotent stem cells or adult stem cell biopsies represent a powerful platform to study human development, drug testing, and disease modeling in vitro, and serve as a cell source for tissue regeneration and therapeutic advances in vivo. Synthetic hydrogels can be engineered to serve as analogs of the extracellular matrix to support HIO growth and differentiation. These hydrogels allow for tuning the mechanical and biochemical properties of the matrix, offering an advantage over biologically derived hydrogels such as MatrigelTM ...
November 21, 2023: Advanced Materials
#29
JOURNAL ARTICLE
Zhou Jiang, Mengjie Cui, Li Qian, Yongguang Jiang, Liang Shi, Yiran Dong, Junxia Li, Yanxin Wang
Iodate (IO3 - ) can be abiotically reduced by Fe(II) or biotically reduced by the dissimilatory Fe(III)-reducing bacterium Shewanella oneidensis (MR-1) via its DmsEFAB and MtrCAB. However, the intermediates and stoichiometry between the Fe(II) and IO3 - reaction and the relative contribution of abiotic and biotic IO3 - reduction by biogenic Fe(II) and MR-1 in the presence of Fe(III) remain unclear. In this study, we found that abiotic reduction of IO3 - by Fe(II) produced intermediates HIO and I- at a ratio of 1:2, followed by HIO disproportionation to I- and IO3 - ...
November 16, 2023: Environmental Science & Technology
#30
JOURNAL ARTICLE
Victoria Poplaski, Carolyn Bomidi, Amal Kambal, Hoa Nguyen-Phuc, Sara C Di Rienzi, Heather A Danhof, Xi-Lei Zeng, Linda A Feagins, Nan Deng, Eduardo Vilar, Florencia McAllister, Cristian Coarfa, Soyoun Min, Hyun Jung Kim, Richa Shukla, Robert Britton, Mary K Estes, Sarah E Blutt
Cronkhite-Canada Syndrome (CCS) is a rare, noninherited polyposis syndrome affecting 1 in every million individuals. Despite over 50 years of CCS cases, the etiopathogenesis and optimal treatment for CCS remains unknown due to the rarity of the disease and lack of model systems. To better understand the etiology of CCS, we generated human intestinal organoids (HIOs) from intestinal stem cells isolated from 2 patients. We discovered that CCS HIOs are highly proliferative and have increased numbers of enteroendocrine cells producing serotonin (also known as 5-hydroxytryptamine or 5HT)...
November 1, 2023: Journal of Clinical Investigation
#31
JOURNAL ARTICLE
Gautam Mehta, Antonio Riva, Maria Pilar Ballester, Eva Uson, Montserrat Pujadas, Ângela Carvalho-Gomes, Ivan Sahuco, Ariadna Bono, Federico D'Amico, Raffaela Viganò, Elena Diago, Beatriz Tormo Lanseros, Elvira Inglese, Dani Martinez Vazquez, Rajni Sharma, Hio Lam Phoebe Tsou, Nicola Harris, Annelotte Broekhoven, Marjolein Kikkert, Shessy P Torres Morales, Sebenzile K Myeni, Mar Riveiro-Barciela, Adriana Palom, Nicola Zeni, Alessandra Brocca, Annarosa Cussigh, Sara Cmet, Desamparados Escudero-García, Matteo Stocco, Leonardo Antonio Natola, Donatella Ieluzzi, Veronica Paon, Angelo Sangiovanni, Elisa Farina, Clara di Benedetto, Yolanda Sánchez-Torrijos, Ana Lucena-Varela, Eva Román, Elisabet Sánchez, Rubén Sánchez-Aldehuelo, Julia López-Cardona, Itzel Canas-Perez, Christine Eastgate, Dhaarica Jeyanesan, Alejandro Esquivel Morocho, Simone Di Cola, Lucia Lapenna, Giacomo Zaccherini, Deborah Bongiovanni, Paola Zanaga, Katia Sayaf, Sabir Hossain, Javier Crespo, Mercedes Robles-Díaz, Antonio Madejón, Helena Degroote, Javier Fernández, Marko Korenjak, Xavier Verhelst, Javier García-Samaniego, Raúl J Andrade, Paula Iruzubieta, Gavin Wright, Paolo Caraceni, Manuela Merli, Vishal C Patel, Amir Gander, Agustín Albillos, Germán Soriano, Maria Francesca Donato, David Sacerdoti, Pierluigi Toniutto, Maria Buti, Christophe Duvoux, Paolo Antonio Grossi, Thomas Berg, Wojciech G Polak, Massimo Puoti, Anna Bosch-Comas, Luca Belli, Patrizia Burra, Francesco Paolo Russo, Minneke Coenraad, José Luis Calleja, Giovanni Perricone, Marina Berenguer, Joan Claria, Richard Moreau, Vicente Arroyo, Paolo Angeli, Cristina Sánchez, Javier Ampuero, Salvatore Piano, Shilpa Chokshi, Rajiv Jalan
BACKGROUND: Vaccine hesitancy and lack of access remain major issues in disseminating COVID-19 vaccination to liver patients globally. Factors predicting poor response to vaccination and risk of breakthrough infection are important data to target booster vaccine programs. The primary aim of the current study was to measure humoral responses to 2 doses of COVID-19 vaccine. Secondary aims included the determination of factors predicting breakthrough infection. METHODS: COVID-19 vaccination and Biomarkers in cirrhosis And post-Liver Transplantation is a prospective, multicenter, observational case-control study...
November 1, 2023: Hepatology Communications
#32
JOURNAL ARTICLE
Jianjun Zhang, Guojun Zhou, Hio-Ieng Un, Fulu Zheng, Kamil Jastrzembski, Mingchao Wang, Quanquan Guo, David Mücke, Haoyuan Qi, Yang Lu, Zhiyong Wang, Yan Liang, Markus Löffler, Ute Kaiser, Thomas Frauenheim, Aurelio Mateo-Alonso, Zhehao Huang, Henning Sirringhaus, Xinliang Feng, Renhao Dong
Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) have emerged as a new class of crystalline layered conducting materials that hold significant promise for applications in electronics and spintronics. However, current 2D c-MOFs are mainly made from organic planar ligands, whereas layered 2D c-MOFs constructed by curved or twisted ligands featuring novel orbital structures and electronic states remain less developed. Herein, we report a Cu-catecholate wavy 2D c-MOF (Cu3 (HFcHBC)2 ) based on a fluorinated core-twisted contorted hexahydroxy-hexa-cata-hexabenzocoronene (HFcHBC) ligand...
October 18, 2023: Journal of the American Chemical Society
#33
JOURNAL ARTICLE
Julia Adler-Milstein, Ariel Linden, Renee Y Hsia, Jordan Everson
OBJECTIVE: To use more precise measures of which hospitals are electronically connected to determine whether health information exchange (HIE) is associated with lower emergency department (ED)-related utilization. MATERIALS AND METHODS: We combined 2018 Medicare fee-for-service claims to identify beneficiaries with 2 ED encounters within 30 days, and Definitive Healthcare and AHA IT Supplement data to identify hospital participation in HIE networks (HIOs and EHR vendor networks)...
December 22, 2023: Journal of the American Medical Informatics Association: JAMIA
#34
JOURNAL ARTICLE
Hio Kuan Wu, Jing Wang, Guanhui Chen, Xiaoqiong Huang, Feilong Deng, Yiming Li
OBJECTIVES: To examine the effect of novel prefabricated auxiliary devices with different geometric features called Scan Body Clasp (SBC) at different levels on the accuracy of intraoral scanning of complete-arch with multiple implants. METHODS: An edentulous maxilla 4-implant model and SBCs with different geometric features (flat or curved) were fabricated by a 3D printer (AccuFab-C1s, 3DShining, Hangzhou, China). Test scans were performed using an intraoral scanner (Aoralscan 3, 3DShining, Hangzhou, China) software version 1...
September 13, 2023: Journal of Dentistry
#35
JOURNAL ARTICLE
Hio-Been Han, Hee-Sup Shin, Yong Jeong, Jisoo Kim, Jee Hyun Choi
The medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) are involved in the regulation of defensive behavior under threat, but their engagement in flexible behavior shifts remains unclear. Here, we report the oscillatory activities of mPFC-BLA circuit in reaction to a naturalistic threat, created by a predatory robot in mice. Specifically, we found dynamic frequency tuning among two different theta rhythms (~5 or ~10 Hz) was accompanied by agile changes of two different defensive behaviors (freeze-or-flight)...
September 12, 2023: Proceedings of the National Academy of Sciences of the United States of America
#36
JOURNAL ARTICLE
Ka Man Cheung, Hio Lam Chong, Zhuolun Jiang, To Ngai
The pervasive presence of plastic packaging has led to significant environmental contamination due to excessive reliance on petrochemicals and the inherent non-biodegradability of these materials. Both bacterial cellulose (BC) and chitosan (CT) films offer a promising option for food packaging purposes due to their sturdy mechanical strength, biodegradability, environmentally friendly manufacturing process, and non-toxic composition. However, the considerable moisture absorption capacity of these eco-friendly materials has hindered their extensive use, as it leads to a reduction in their strength and ability to serve as a barrier...
September 4, 2023: Soft Matter
#37
JOURNAL ARTICLE
Hio Wa Mak, David M Lydon-Staley, Erika Lunkenheimer, Mark H C Lai, Gregory M Fosco
Daily emotion dynamics provide valuable information about individuals' emotion processes as they go about their lives. Emotion dynamics such as emotion levels (mean), emotion variability (degree of fluctuation), and emotion network density (strength of temporal connections among emotions) are associated with risks for various psychopathology in youth and adults. Prior work has shown that caregivers and friends play crucial socializing roles in adolescent emotional well-being, but less is known about their roles in daily emotion dynamics...
February 2023: Social Development
#38
JOURNAL ARTICLE
Huimei Pan, Boqiang Li, Jie Yang, Wenzhe Liu, Wang Luo, Baiyang Chen
This study revisited a list of inorganic iodine species on their detections and conversions under different water conditions. Several surprising results were found, e.g., UV-vis spectrophotometry is the only reliable method for I3 - and I2 determinations with coexisting I- /IO3 - /IO4 - , while alkaline eluent of IC and LC columns can convert them into I- completely; IO4 - can be converted into IO3 - completely in IC columns and partly in LC columns; a small portion of IO3 - was reduced to I- in LC columns...
August 28, 2023: Journal of Hazardous Materials
#39
JOURNAL ARTICLE
Joon Beom Park, Kangeun Ko, Yang Hyun Baek, Woo Young Kwon, Sunghwan Suh, Song-Hee Han, Yun Hak Kim, Hye Young Kim, Young Hyun Yoo
Hepatic iron overload (HIO) is a hallmark of nonalcoholic fatty liver disease (NAFLD) with a poor prognosis. Recently, the role of hepatic erythrophagocytosis in NAFLD is emerging as a cause of HIO. We undertook various assays using human NAFLD patient pathology samples and an in vivo nonalcoholic steatohepatitis (NASH) mouse model named STAMTM . To make the in vitro conditions comparable to those of the in vivo NASH model, red blood cells (RBCs) and platelets were suspended and subjected to metabolic and inflammatory stresses...
August 16, 2023: International Journal of Molecular Sciences
#40
JOURNAL ARTICLE
α- and β-(C 4 H 5 N 2 O)(IO 3 )·HIO 3 : Two SHG Materials Based on Organic-Inorganic Hybrid Iodates.
Qian-Qian Chen, Chun-Li Hu, Ming-Zhi Zhang, Bing-Xuan Li, Jiang-Gao Mao
Organic-inorganic hybrid nonlinear optical (NLO) materials are highly anticipated because of the integration of both merits of the organic and inorganic moieties. Herein, the 2-pyrimidinone cation (C4 H5 N2 O)+ has been incorporated into the iodate system to form two polymorphic organic-inorganic hybrid iodates, namely, α- and β-(C4 H5 N2 O)(IO3 )·HIO3 . They crystallize in different polar space groups ( Ia and Pca 21 ), and their structures feature one-dimensional (1D) chain structures composed of (C4 H5 N2 O)+ cations, IO3 - anions, and HIO3 molecules interconnected via hydrogen bonds...
August 11, 2023: Inorganic Chemistry
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