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REVIEW
Giandomenico Roviello, Matteo Santoni, Guru P Sonpavde, Martina Catalano
Cisplatin-based chemotherapy is currently the first-line standard of care for patients with metastatic urothelial cancer (mUC); however, up to 50% of patients are ineligible for cisplatin, necessitating alternative treatment options. Immune checkpoint inhibitors have been shown to be effective in cisplatin-ineligible patients. However, despite advances in the first-line setting, the prognosis remains poor, and challenges persist in selecting optimal therapies, treatment sequences and combination regimens. Maintenance therapy with avelumab revealed improved overall (OS) and progression-free survival (PFS) compared with best supportive care alone in patients with platinum-responsive mUC...
May 3, 2024: Nature Reviews. Urology
#2
COMPARATIVE STUDY
CaiXia Chen, Jiao Qin, ChongJian Wang, HaoTian Huang, HongYuan Li, Zhi Wen, Yang Liu, XueSong Yang
PURPOSE: There is still controversy regarding the safety and efficacy of cold knife visual internal urethrotomy and laser incisions for the treatment of urethral stricture. This study aims to compare the results of postoperative long-term and short-term maximum urinary flow rates (Qmax), surgical time, postoperative complications, and 1-year recurrence rates between the cold knife and laser surgery. METHODS: We searched databases including Embase, PubMed, Cochrane, and Clinical Trials...
May 3, 2024: Medicine (Baltimore)
#3
JOURNAL ARTICLE
Josephine Hirsch, N Valeska Halstead, Theresa Meyer, James T Rague, Soojin Kim, Ilina Rosoklija, Stephanie Kielb, Jill E Larson, Vineeta T Swaroop, Robin M Bowman, Earl Y Cheng, Diana K Bowen, Elizabeth B Yerkes, David I Chu
PURPOSE: To assess associations between health-related quality of life (HRQOL), bladder-related QOL, bladder symptoms, and bladder catheterization route among adolescents and young adults (AYA) with spina bifida (SB). MATERIALS AND METHODS: Clinical questionnaires administered to individuals ≥ 12-years-old requiring catheterization between June 2019-March 2020 in a SB center were retrospectively analyzed. Questionnaires were completed in English or Spanish independently or with caregiver assistance...
May 3, 2024: Journal of Urology
#4
REVIEW
Yerbol Iskakov, Rustam Omarbayev, Rinat Nugumanov, Timur Turgunbayev, Yerkebulan Yermaganbetov
UNLABELLED: Erectile dysfunction is observed in about 50% of men. It has been found that diabetes mellitus increases its prevalence to 19-86.3%, necessitating attention to a therapeutic strategy. Among the available treatment methods, intracavernosal injections of mesenchymal stem cells have proven to be particularly effective. OBJECTIVE: The purpose of study is to assess and analyse the effectiveness of their use in the treatment of erectile dysfunction in patients with diabetes mellitus...
May 3, 2024: International Braz J Urol: Official Journal of the Brazilian Society of Urology
#5
REVIEW
Parth U Thakker, Maxwell Sandberg, Ashok K Hemal, Alejandro R Rodriguez
BACKGROUND AND OBJECTIVE: Salvage robot assisted radical prostatectomy (sRARP) is performed for patients with biochemical or biopsy proven, localized prostate cancer recurrences after radiation or ablative therapies. Traditionally, sRARP has been avoided by lower volume surgeons due to technical demand and high complication rates. Post-radiation sRARP outcomes studies exist but remain few in number. With increasing use of whole gland and focal ablative therapies, updates on sRARP in this setting are needed...
May 3, 2024: International Braz J Urol: Official Journal of the Brazilian Society of Urology
#6
REVIEW
Bárbara Vieira Lima Aguiar Melão, Lucas Guimarães Campos Roriz de Amorim, Murilo Ribeiro Sanches, Giovanna Veiga Gomes, Douglas Mesadri Gewehr, Luis Henrique de Oliveira Moreira, Thaise Pedreira da Silva, Matheus de Melo Lobo, Gustavo Ruschi Bechara
INTRODUCTION: Chemotherapy and radiation therapy are considered standard treatments for stage II seminoma patients; however, these therapies are associated with long-term toxicities. Recently, retroperitoneal lymph node dissection has emerged as an alternative strategy, and the first three phase II trials were published in 2023 with promising results. The present study conducted a systematic review and meta-analysis to evaluate this surgery as an alternative treatment for stage IIA/B seminoma patients...
May 3, 2024: International Braz J Urol: Official Journal of the Brazilian Society of Urology
#7
JOURNAL ARTICLE
Nazih Khater, Anna G Morris, Delena M Vanvalkenburg, Andrew J Garcia, Kevin Jin, Shahab Ahmadzadeh, Sahar Shekoohi, Elyse M Cornett, Alan David Kaye
Obesity is associated with many significant physiological changes. These considerations are important to surgery, especially in urological procedures. Obese patients often undergo surgical procedures and are at higher risk of complications. This investigation reviews physiological and anaesthesia considerations for obese and morbidly obese patients. In addition, urological surgeries and procedures should be considered for these higher risk patients. Clinical anaesthesiologists must use detailed assessment and, when appropriate, consultation in developing safe anaesthesia plans for these patients...
May 3, 2024: Turkish Journal of Anaesthesiology and Reanimation
#8
REVIEW
Rikiya Taoka, Mikio Sugimoto
To preserve the bladder without compromising survival, further treatments need to be optimized to prevent the recurrence and progression of non-muscle invasive bladder cancer. In clinical practice, transurethral resection of bladder tumors is essential for bladder cancer management. The primary goal of surgery is to achieve accurate pathological evaluation and complete resection of bladder cancer; high resection quality is required for the procedure. A representative surrogate indicator of the resection quality is the presence of the detrusor muscle in the resection specimen...
May 3, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
#9
JOURNAL ARTICLE
Tamer A Abouelgreed, Mohamed A Amer, Hassan Mamdouh, Ahmed F El-Sherbiny, Hany Aboelwafa, Sameh F Fahmy, Omar A Omar, Mohammed Abdelshakour, Mohammad Elesawy, Mohamed Sonbol, Ahmed N Maawad, Osama K Elsayed
OBJECTIVE: This study aims to investigate the current evidence regarding the impact of oral antioxidant supplementation on semen parameters of infertile men. MATERIALS AND METHODS: We conducted a systematic search of PubMed, and Cochrane electronic databases, adhering to modified Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The focus was on studies exploring the effects of antioxidant therapy on infertile men, with an examination of antioxidants in terms of types, doses, rationale for use, and their impact on semen parameters measures...
May 2, 2024: Archivio Italiano di Urologia, Andrologia
#10
JOURNAL ARTICLE
Sei Naito
No abstract text is available yet for this article.
May 3, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
#11
REVIEW
Christopher J De Jonge, Christopher L R Barratt, R John Aitken, Richard A Anderson, Peter Baker, David Y L Chan, Mark P Connolly, Michael L Eisenberg, Nicolas Garrido, Niels Jørgensen, Sarah Kimmins, Csilla Krausz, Robert I McLachlan, Craig Niederberger, Moira K O'Bryan, Allan Pacey, Lærke Priskorn, Satu Rautakallio-Hokkanen, Gamal Serour, Joris A Veltman, Donna L Vogel, Mónica H Vazquez-Levin
BACKGROUND: The widespread interest in male reproductive health (MRH), fueled by emerging evidence, such as the global decline in sperm counts, has intensified concerns about the status of MRH. Consequently, there is a pressing requirement for a strategic, systematic approach to identifying critical questions, collecting pertinent information, and utilizing these data to develop evidence-based strategies. The methods for addressing these questions and the pathways toward their answers will inevitably vary based on the variations in cultural, geopolitical, and health-related contexts...
2024: Human Reproduction Open
#12
REVIEW
Chengheng Liao, Lianxin Hu, Qing Zhang
The distinct pathological and molecular features of kidney cancer in adaptation to oxygen homeostasis render this malignancy an attractive model for investigating hypoxia signalling and potentially developing potent targeted therapies. Hypoxia signalling has a pivotal role in kidney cancer, particularly within the most prevalent subtype, known as renal cell carcinoma (RCC). Hypoxia promotes various crucial pathological processes, such as hypoxia-inducible factor (HIF) activation, angiogenesis, proliferation, metabolic reprogramming and drug resistance, all of which contribute to kidney cancer development, growth or metastasis formation...
May 2, 2024: Nature Reviews. Urology
#13
REVIEW
Giulia Marvaso, Barbara Alicja Jereczek-Fossa, Mattia Zaffaroni, Maria Giulia Vincini, Giulia Corrao, Nicolaus Andratschke, Ehsan H Balagamwala, Jens Bedke, Oliver Blanck, Umberto Capitanio, Rohann J M Correa, Gert De Meerleer, Ciro Franzese, Aurora Gaeta, Sara Gandini, Cristina Garibaldi, Peter C Gerszten, Silke Gillessen, William R Grubb, Matthias Guckenberger, Raquibul Hannan, Pavan M Jhaveri, Mirjana Josipovic, Linda G W Kerkmeijer, Eric J Lehrer, Magnus Lindskog, Alexander V Louie, Quynh-Nhu Nguyen, Piet Ost, David A Palma, Giuseppe Procopio, Maddalena Rossi, Michael Staehler, Alison C Tree, Yat Man Tsang, Nicholas Van As, Nicholas G Zaorsky, Thomas Zilli, David Pasquier, Shankar Siva
The purpose of this European Society for Radiotherapy and Oncology (ESTRO) project, endorsed by the European Association of Urology, is to explore expert opinion on the management of patients with oligometastatic and oligoprogressive renal cell carcinoma by means of stereotactic ablative radiotherapy (SABR) on extracranial metastases, with the aim of developing consensus recommendations for patient selection, treatment doses, and concurrent systemic therapy. A questionnaire on SABR in oligometastatic renal cell carcinoma was prepared by a core group and reviewed by a panel of ten prominent experts in the field...
May 2024: Lancet Oncology
#14
REVIEW
Piero Alberti, Jola Bytyci, Jessy Jindal, Michael Stephanou, Lucy Thompson, Yedidiah Tilahun, Yuxin Ying, Annabel Killen, Emery Manirambona, Alliance Niyukuri, Kokila Lakhoo, Kathryn Ford
BACKGROUND: Literature on paediatric surgical conditions in low- and middle-income countries (LMICs) remains limited. As a common emergency, timely treatment of testicular torsion acts as a benchmark of adequate emergency service delivery in paediatric surgery. This scoping study aims to synthesise all existing literature on paediatric testicular torsion in LMICs. METHODS: A database search was conducted by the OxPLORE global paediatric surgery research group to identify studies containing the terms 'testicular torsion' or 'acute scrotum' originating from LMICs...
May 2, 2024: Pediatric Surgery International
#15
JOURNAL ARTICLE
Naoki Fujita, Takuro Iwane, Yoshihiro Tamura, Teppei Okamoto, Hayato Yamamoto, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Wataru Kobayashi, Chikara Ohyama
OBJECTIVES: Several systematic reviews and meta-analyses have reported positive relationships between erectile dysfunction (ED) and periodontal disease. However, no study has evaluated the relationships of occlusal support status and the number of remaining teeth with ED. The aim of the present study was to investigate the relationships between ED and the remaining teeth number, periodontal disease, and occlusal support status. METHODS: This study included 400 community-dwelling men...
May 2, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
#16
REVIEW
R E Akhigbe, A F Odetayo, T M Akhigbe, M A Hamed, P J Ashonibare
Testicular torsion is a urological emergency that involves the twisting of the spermatic cord along its course. Compelling pieces of evidence have implicated oxidative stress-sensitive signaling in pathogenesis of testicular I/R injury. Although, surgical detorsion is the mainstay management; blockade of the pathways involved in the pathogenesis may improve the surgical outcome. Experimental studies using various testicular I/R models have been reported in a bid to explore the mechanisms associated with testicular I/R and evaluate the benefits of potential therapeutic measures; however, most are limited by their shortcomings...
May 15, 2024: Heliyon
#17
JOURNAL ARTICLE
Po-Ming Chow, Tyler Trump, Howard B Goldman
INTRODUCTION: Sacral neuromodulation (SNM) and onabotulinumtoxinA (BoNTA) injection are third-line therapies for overactive bladder (OAB). Although the efficacy of each third-line treatment has been well established in clinical trials, there is far less information about performing one third-line therapy after the other. Our aim is thus to investigate the outcomes of post-SNM BoNTA and post-BoNTA SNM as "second" third-line treatments. METHODS: We retrospectively reviewed all OAB patients who had both SNM and BoNTA between 2013 and 2022...
May 2, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
#18
JOURNAL ARTICLE
T R Govender, J Scribante, T Govender, A Withers, J A Loveland
BACKGROUND: The Global Initiative for Children's Surgery group published the Optimal Resources for Children's Surgery (OReCS) document outlining the essential criteria and strategies for children's surgical care in low-resource settings. Limited data exist on subspecialties in pediatric surgery and their contribution to global surgery efforts. The study aimed to evaluate the development of subspecialty units within Chris Hani Baragwanath Academic Hospital (CHBAH) Department of Pediatric Surgery (DPS) from January 1, 2018 to December 31, 2021 using selected OReCS strategies for the improvement of pediatric surgery...
May 1, 2024: World Journal of Surgery
#19
JOURNAL ARTICLE
Xinrui Long, Jiaqi Chen, Jiaqi Li, Zhonglin Luo
Conducting clinical trials can evaluate the effectiveness and safety of surgical robots. To promote the advancement of academic robotic programs in surgery, this study captures the development trend and research hotspots of clinical trials related to surgical robots by bibliometric analysis. Bibliometrix package in R software was used to analyze the publication year, authors, countries, institutes, and journals. The visualization maps of keywords were formed using VOSviewer. The keywords with the strongest citation bursts and the institutional collaboration map were created by CiteSpace...
May 2, 2024: Journal of Robotic Surgery
#20
JOURNAL ARTICLE
Anthony Hiffa, Merry Chen, Faizan Boghani, Michael D Oberle, W Carter Reed, Sherita A King, John De Caro, Martha K Terris, Matthew N Simmons, Thomas E Dykes
PURPOSE: Transrectal ultrasound-guided prostate biopsy (TRUS-Bx) is associated with a 1-8% risk of post-biopsy sepsis (PBS). A recent study described an isopropyl alcohol needle washing protocol that significantly decreased PBS rates. The current study examined the efficacy of this technique in our clinic population. MATERIALS AND METHODS: Data were reviewed for 1250 consecutive patients undergoing TRUS-Bx at the Charlie Norwood VA Medical Center from January 2017 to January 2023...
May 1, 2024: World Journal of Urology
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