Jenifer Goldman Fraser, Carmen Rosa Noroña, Jessica Dym Bartlett, Jie Zhang, Joseph Spinazzola, Jessica L Griffin, Crystaltina Montagna, Marybeth Todd, Ruth Bodian, Beth Barto
Young children who experience abuse, neglect, domestic violence, and other interpersonal forms of trauma are at risk for developing complex psychological trauma. Timely referrals by child welfare services for trauma evaluation and intervention is critical, particularly during the developmentally-sensitive period of birth to three. However, few screening instruments exist that are feasible for implementation in child welfare services and none have reported psychometric data for children under three. The aim of this exploratory, retrospective study was to examine developmental differences in detection rates of two brief trauma screening scales, comparing outcomes for toddlers (age 1 and 2 years) and preschoolers (age 3 to 6 years), using the evaluation data from a statewide child welfare demonstration project...
September 2019: Journal of Child & Adolescent Trauma
N Normann, G Tietz, A Kühn, C Fuchs, V Balau, K Schulz, J Kolata, T Schuerholz, A Petersmann, S Stentzel, L Steil, S O Kuhn, K Meissner, U Völker, M Nauck, I Steinmetz, D Raafat, M Gründling, B M Bröker
Infections are often caused by pathobionts, endogenous bacteria that belong to the microbiota. Trauma and surgical intervention can allow bacteria to overcome host defences, ultimately leading to sepsis if left untreated. One of the main defence strategies of the immune system is the production of highly specific antibodies. In the present proof-of-concept study, plasma antibodies against 9 major pathogens were measured in sepsis patients, as an example of severe systemic infections. The binding of plasma antibodies to bacterial extracellular proteins was quantified using a semi-automated immunoblot assay...
April 17, 2020: European Cells & Materials
Mithun R Suresh, Krystal K Valdez-Delgado, Christopher A VanFosson, Jennifer D Trevino, Elizabeth A Mann-Salinas, Stacy A Shackelford, Amanda M Staudt
BACKGROUND: Role 2 forward surgical teams provide damage control resuscitation and surgery for life- and limb-threatening injuries. These teams have limited resources and personnel, so understanding the anatomic injury patterns seen by these teams is vital for providing adequate training and preparation prior to deployment. The objective of this study was to describe the spectrum of injuries treated at Role 2 facilities in Afghanistan. METHODS: Using Department of Defense Trauma Registry data, a retrospective, secondary data analysis was conducted...
April 8, 2020: Journal of Trauma and Acute Care Surgery
Marcus Deloney, Kyra Smart, Blaine A Christiansen, Alyssa Panitch
Inflammation following joint trauma contributes to cartilage degradation and progression of post traumatic osteoarthritis (PTOA). Therefore, drug delivery vehicles that deliver effective anti-inflammatory treatments have the potential to prevent PTOA. We have developed solid and hollow, thermoresponsive nanoparticles for the controlled release of our anti-inflammatory MK2-inhibiting (MK2i) peptide for intra-articular injection to halt inflammation that contributes to the advancement of PTOA. This system exploits the thermosensitive characteristic of N-isopropyl acrylamide (NIPAm) to transition phases when passing through its lower critical solution temperature (LCST)...
April 9, 2020: Journal of Controlled Release
Yiyuan Duan, Honghao Zheng, Zehua Li, Yuejun Yao, Jie Ding, Xuemei Wang, Jayachandra Reddy Nakkala, Deteng Zhang, Zhaoyi Wang, Xingang Zuo, Xiaowen Zheng, Jun Ling, Changyou Gao
The immune system responds immediately to tissue trauma and to biomaterial implants under the participation of M1/M2 macrophages polarization. The surface properties of biomaterials can significantly influence the tissue repair progress through modulating the macrophage functions. In this study, the surface of poly(propylene fumarate) polyurethane films (PPFU) is grafted with a same density of enantiomeric poly-l-lysine (PPFU-g-PLL) and poly-d-lysine (PPFU-g-PDL), leading to a similar level of enhanced surface wettability for the PPFU-g-PLL and PPFU-g-PDL...
July 2020: Biomaterials
Yunsheng Dong, Huahong Zhuang, Yan Hao, Lin Zhang, Qiang Yang, Yufei Liu, Chunxiao Qi, Shufang Wang
Introduction: Chronic trauma repair is an important issue affecting people's healthy lives. Thermo-sensitive hydrogel is injectable in situ and can be used to treat large-area wounds. In addition, antioxidants play important roles in promoting wound repair. Methods: The purpose of this research was to prepare a novel thermo-sensitive hydrogel-poly(N-isopropyl-acrylamide)/poly(γ-glutamic acid) (PP) loaded with superoxide dismutase (SOD) to improve the effect for trauma treatment...
2020: International Journal of Nanomedicine
Monica B Setien, Kylie R Smith, Kaleb Howard, Kathleen Williams, Steve T Suhr, Erin K Purcell
BACKGROUND: Induced pluripotent stem cells (iPSCs) may be an advantageous source of neuronal cells to repair damage due to neurological disorders or trauma. Additionally, they are promising candidates to develop models to study underlying mechanisms of neurodegenerative diseases. While successful neural differentiation of iPSCs has been reported in mice, protocols detailing the generation of neural cells from rat iPSCs are relatively limited, and their optimization by manipulating cell culture methods has remained unexplored...
March 18, 2020: Journal of Neuroscience Methods
Anita F Quigley, Rhys Cornock, Tharun Mysore, Javad Foroughi, Magdalena Kita, Joselito M Razal, Jeremy Crook, Simon E Moulton, Gordon G Wallace, Robert M I Kapsa
Engineering of 3D regenerative skeletal muscle tissue constructs (skMTCs) using hydrogels containing muscle precursor cells (MPCs) is of potential benefit for repairing Volumetric Muscle Loss (VML) arising from trauma (e.g., road/industrial accident, war injury) or for restoration of functional muscle mass in disease (e.g., Muscular Dystrophy, muscle atrophy). Additive Biofabrication (AdBiofab) technologies make possible fabrication of 3D regenerative skMTCs that can be tailored to specific delivery requirements of VML or functional muscle restoration...
2020: Frontiers in Chemistry
Shuai Liu, Yajie Pu, Rong Yang, Xin Liu, Penghui Wang, Xiaoxue Wang, Yanhan Ren, Xiaoyan Tan, Zhiwen Ye, Bo Chi
Although mesenchymal stem cells (MSCs) encapsulated with bionic scaffolds have been widely used in treating trauma induced cartilage defects, challenges still persist for these hydrogel scaffolds to create suitable shelters for the MSCs and guide their behaviors. In this work, novel biomimetic hydrogel scaffolds were prepared by thiol-ene Michael addition between glycidyl methacrylate (GMA)-modified poly (γ-glutamic acid) (γ-PGA-GMA) and DL-1,4-Dithiothreitol (DTT) for cartilage tissue engineering. Sodium tetraborate decahydrate was added into the system to connect with DTT through hydrogen-bond interaction and served as catalyst for thiol-ene Michael addition to strengthen the intensity of the hydrogel...
February 27, 2020: International Journal of Biological Macromolecules
Rodrigo Moreira Cunha, Francisley Ávila Souza, Henrique Hadad, Pier Paolo Poli, Carlo Maiorana, Paulo Sérgio Perri Carvalho
STATEMENT OF PROBLEM: Correct implant placement by means of a pretreatment planning software program is still subject to deviations between the planned and achieved implant positions. Inaccuracy at this level may have drastic consequences, including neurovascular trauma. Further data are therefore needed to evaluate the accuracy of such computer-guided implant planning software programs. PURPOSE: The purpose of this clinical study was to evaluate the accuracy of computer-guided implant surgery associated with prototyped surgical guides...
February 25, 2020: Journal of Prosthetic Dentistry
Carla Sofia Moura, João Carlos Silva, Sofia Faria, Paulo Rui Fernandes, Cláudia Lobato da Silva, Joaquim Manuel Sampaio Cabral, Robert Linhardt, Paulo Jorge Bártolo, Frederico Castelo Ferreira
Cartilage defects resultant from trauma or degenerative diseases (e.g., osteoarthritis) can potentially be repaired using tissue engineering (TE) strategies combining progenitor cells, biomaterial scaffolds and bio-physical/chemical cues. This work examines promoting chondrogenic differentiation of human bone marrow mesenchymal stem/stromal cells (BM-MSCs) by combining the effects of modified poly (ε-caprolactone) (PCL) scaffolds hydrophilicity and chondroitin sulfate (CS) supplementation in a hypoxic 5% oxygen atmosphere...
February 25, 2020: Journal of Bioscience and Bioengineering
Siwei Li, Francesca Tallia, Ali A Mohammed, Molly M Stevens, Julian R Jones
We report that 3-D printed scaffold channel size can direct bone marrow derived stem cell differentiation. Treatment of articular cartilage trauma injuries, such as microfracture surgery, have limited success because durability is limited as fibrocartilage forms. A scaffold-assisted approach, combining microfracture with biomaterials has potential if the scaffold can promote articular cartilage production and share load with cartilage. Here, we investigated human bone marrow derived stromal cell (hBMSC) differentiation in vitro in 3-D printed silica/poly(tetrahydrofuran)/poly(ε-caprolactone) hybrid scaffolds with specific channel sizes...
February 26, 2020: Biomaterials Science
Abdul Malik Mujahid, Farrukh Aslam Khalid, Noor Ali, Yawar Sajjad, Husnain Khan, Moazzam Nazeer Tarar
OBJECTIVE: To compare outcome of split thickness graft with and without vacuum-assisted closure over the scalp soft tissue defects in terms of graft take and complications. STUDY DESIGN: Randomised controlled trial. PLACE AND DURATION OF STUDY: Department of Plastic Surgery, Jinnah Burns and Reconstructive Surgery Centre, Lahore, from June 2017 to June 2018. METHODOLOGY: Patients with scalp soft tissue defects were recruited for the study...
February 2020: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Zahra Nazemi, Mohammad Sadegh Nourbakhsh, Sahar Kiani, Yasaman Heydari, Mohammad Kazemi Ashtiani, Hamed Daemi, Hossein Baharvand
Spinal cord injury (SCI) induces pathological and inflammatory responses that create an inhibitory environment at the site of trauma, resulting in axonal degeneration and functional disability. Combination therapies targeting multiple aspects of the injury, will likely be more effective than single therapies to facilitate tissue regeneration after SCI. In this study, we designed a dual-delivery system consisting of a neuroprotective drug, minocycline hydrochloride (MH), and a neuroregenerative drug, paclitaxel (PTX), to enhance tissue regeneration in a rat hemisection model of SCI...
February 5, 2020: Journal of Controlled Release
Ferdows Afghah, Mohib Ullah, Jamal Seyyed Monfared Zanjani, Pınar Akkuş Süt, Ozlem Sen, Melis Emanet, Burcu Saner Okan, Mustafa Culha, Yusuf Menceloglu, M Yildiz, Bahattin Koc
Scaffold-based tissue engineering approaches have been commonly used for skin regeneration or wound healings caused by diseases or trauma. For an ideal complete healing process, scaffold structures need to meet the criteria of biocompatibility, biodegradability, and antimicrobial properties, as well as to provide geometrical necessities for the regeneration of damaged tissue. In this study, design, synthesis and characterization of a three dimensional (3D) printable copolymer based on polycaprolactone-block-poly(1,3-propylene succinate)‎ (PCL-PPSu) including anti-microbial silver particles is presented...
February 7, 2020: Biomedical Materials
John L Daristotle, Lung W Lau, Metecan Erdi, Joseph Hunter, Albert Djoum, Priya Srinivasan, Xiaofang Wu, Mousumi Basu, Omar B Ayyub, Anthony D Sandler, Peter Kofinas
Conventional wound dressings are difficult to apply to large total body surface area (TBSA) wounds, as they typically are prefabricated, require a layer of adhesive coating for fixation, and need frequent replacement for entrapped exudate. Large TBSA wounds as well as orthopedic trauma and low-resource surgery also have a high risk of infection. In this report, a sprayable and intrinsically adhesive wound dressing loaded with antimicrobial silver is investigated that provides personalized fabrication with minimal patient contact...
January 2020: Bioengineering & Translational Medicine
Sherry Hamby, Elizabeth Taylor, Kimberly Mitchell, Lisa Jones, Chris Newlin
Although it is well known that victimization is associated with higher trauma symptoms, there is still limited information on the protective factors that can help people thrive after adversity. Using the Resilience Portfolio Model as a framework, this study explores a range of psychological and social strengths in a community sample of youth from the southern U.S.A sample of 440 youth aged 10 to 21 (average age 16.38, SD = 3.04) was recruited from youth-serving organizations. They completed a survey on trauma symptoms, victimization, other adversities, and 16 psychological and social strengths...
January 28, 2020: Journal of Trauma & Dissociation
Stine Lehmann, Kyrre Breivik, Sebastien Monette, Helen Minnis
BACKGROUND: In DSM 5, three disorders are related to trauma and/or maltreatment: Post-traumatic Stress Disorder (PTSD), Reactive Attachment Disorder (RAD) and Disinhibited Social Engagement Disorder (DSED) but how these disorders relate to each other and to traumatic events is unknown. OBJECTIVE: We examined 1. Prevalence of Potentially Traumatic Events (PTEs) and poly-victimization for youths in foster care. 2. Associations between single/multiple PTEs and PTSD, DSED, and the two symptom-clusters that constitute RAD: Failure to seek/accept comfort (RAD A), and Low social-emotional responsiveness/ emotion dysregulation (RAD B)...
March 2020: Child Abuse & Neglect
Ankita Bhat, Judy M Amanor-Boadu, Anthony Guiseppi-Elie
A pH-responsive, poly(2-hydroxyethyl methacrylate) [poly(HEMA)]-based hydrogel has been fashioned into an impedimetric pH sensor for the continual measurement and monitoring of tissue acidosis that can arise due to hemorrhaging trauma. Four hydrogel systems molecularly engineered to influence water distribution and ionic abundance were studied: a cationogenic primary amine, N -(2-aminoethyl) methacrylate (AEMA), a tertiary amine moiety, N , N -(2-dimethylamino)ethyl methacrylate (DMAEMA), and a combined AEMA-DMAEMA formulation...
January 30, 2020: ACS Sensors
Byungho Park, Bryan Taekyung Jung, Won Hyeon Kim, Jong-Ho Lee, Bongju Kim, Jee-Ho Lee
Recently, a hydroxyapatite particle/poly-L-lactide (HA-PLLA) composite device was introduced as an alternative to previous fixation systems. In this study, we used finite element analysis to simulate peak von Mises stress (PVMS) and deformation of bone plates and screws with the following four materials-Ti, Mg alloy, PLLA, and HA-PLLA-at a unilateral mandibular fracture. A three-dimensional virtual mandibular model was constructed, and the fracture surface was designed to run from the left mandibular angle...
January 4, 2020: Materials
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