Tengda Huang, Jingsu Yu, Zupeng Luo, Lin Yu, Siqi Liu, Peng Wang, Mengting Jia, Tian Wu, Weiwei Miao, Lei Zhou, Ziyi Song, Haojie Zhang, Yixing Li
Non-alcoholic fatty liver disease (NAFLD) is a common disease with a multitude of complications. Increasing evidence shows that the dietary supplement with betaine, a natural chemical molecule, can effectively reduce the fat accumulation in the liver. Translational regulation is considered to play a vital role in gene expression, but whether betaine functions through the regulation of gene translational level is still unclear. To this end, RNC-seq (mRNAs bound to ribosome-nascent chain complex sequencing) and RNA-seq co-analyses were performed to identify betaine target genes by using the liver samples from high-fat diet adding betaine treated and high-fat diet treated mice...
August 25, 2021: Biochemical and Biophysical Research Communications