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JOURNAL ARTICLE
Laura C Plantinga, C Barrett Bowling, Courtney Hoge, Charmayne Dunlop-Thomas, Bradley D Pearce, S Sam Lim, Cristina Drenkard
OBJECTIVE: To report the burden and correlates of poor physical performance in a diverse cohort of individuals with SLE. METHODS: In this single-visit study of 446 individuals with SLE from a population-based metropolitan Atlanta cohort, we measured physical performance via the Short Physical Performance Battery [score range, 0-12; intermediate-low (<10) vs. high (≥10)]. We also collected demographic, clinical, and psychosocial variables and examined the associations [adjusted odds ratios (aORs)] of intermediate-low vs...
October 26, 2023: Arthritis Care & Research
#2
JOURNAL ARTICLE
Courtney Hoge, C Barrett Bowling, Charmayne Dunlop-Thomas, Brad D Pearce, Cristina Drenkard, S Sam Lim, Laura C Plantinga
OBJECTIVE: In a study of physical and cognitive functioning among predominantly Black individuals with systemic lupus erythematosus (SLE), we compared remotely administered physical and cognitive performance assessments to those collected in person. METHODS: A subset of participants who completed an in-person visit in our parent study from 2021 to 2022 (n = 30) were recruited to complete a second, remote visit within 28 days. Physical performance (measured by a modified Short Physical Performance Battery [SPPB]; range 0-12; subscale ranges 0-4; higher = better performance) and cognitive performance (episodic and working memory adjusted t-scores, measured using NIH Toolbox) were measured at both visits...
August 15, 2023: ACR open rheumatology
#3
JOURNAL ARTICLE
Hee S Kim, Sang Li, Yi Zheng, Charles G Aldrich
Fat has high energy density and is considered one of the primary energy sources for dogs, however, increasing fat level in dry dog food has been challenging due to the lubrication and limitation of the coating system. The objective was to determine the effect of whole soybeans (WSB) on nutrient digestibility, stool quality, and palatability by dogs. The corn gluten meal, chicken fat, and brewers rice were replaced by WSB at 10, 20, and 30% (WSB10, WSB20, and WSB30, respectively) in the base diet (WSB0). Twelve beagles were randomly assigned...
2023: Frontiers in Veterinary Science
#4
JOURNAL ARTICLE
Hunter Levis, Jacob Weston, Brooke Austin, Bryce Larsen, Matthew Ginley-Hidinger, Sarah E Gullbrand, Brandon Lawrence, Robby D Bowles
BACKGROUND AIMS: Lower back pain is the leading cause of disability worldwide and is often linked to degenerative disc disease (DDD), the breakdown of intervertebral discs. The majority of treatment options for DDD are palliative, with clinicians prescribing medication or physical therapy to return the patient to work. Cell therapies are promising treatment options with the potential to restore functional physiological tissue and treat the underlying causes of DDD. DDD is characterized by biochemical changes in the microenvironment of the disc, including changes in nutrient levels, hypoxia, and changes in pH...
May 27, 2023: Cytotherapy
#5
JOURNAL ARTICLE
Joshua E Gonzalez, Steven A Shea, Nicole P Bowles
OBJECTIVE: To assess the relationship between frequency of cannabis use and sleep duration across age in a large US population (235,667 people). METHODS: Multinomial logistic regression was used to evaluate the association between the frequency of cannabis use and sleep duration using cross sectional data from the 2016-2018 Behavioral Risk Factor Surveillance System. RESULTS: When adjusted for sociodemographic factors, health related variables, and stratified by age we found that young adults (18-44 years) who reported daily-use (≥16 uses a month) had an increased risk ratio (RR [95% CI]) for either short or long sleep (1...
November 17, 2022: Sleep Health
#6
JOURNAL ARTICLE
Ashley J King, Luke Daly, James Rowe, Katherine H Joy, Richard C Greenwood, Hadrien A R Devillepoix, Martin D Suttle, Queenie H S Chan, Sara S Russell, Helena C Bates, James F J Bryson, Patricia L Clay, Denis Vida, Martin R Lee, Áine O'Brien, Lydia J Hallis, Natasha R Stephen, Romain Tartèse, Eleanor K Sansom, Martin C Towner, Martin Cupak, Patrick M Shober, Phil A Bland, Ross Findlay, Ian A Franchi, Alexander B Verchovsky, Feargus A J Abernethy, Monica M Grady, Cameron J Floyd, Matthias Van Ginneken, John Bridges, Leon J Hicks, Rhian H Jones, Jennifer T Mitchell, Matthew J Genge, Laura Jenkins, Pierre-Etienne Martin, Mark A Sephton, Jonathan S Watson, Tobias Salge, Katherine A Shirley, Rowan J Curtis, Tristram J Warren, Neil E Bowles, Finlay M Stuart, Luigia Di Nicola, Domokos Györe, Adrian J Boyce, Kathryn M M Shaw, Tim Elliott, Robert C J Steele, Pavel Povinec, Matthias Laubenstein, David Sanderson, Alan Cresswell, Anthony J T Jull, Ivan Sýkora, Sanjana Sridhar, Richard J Harrison, Francesca M Willcocks, Catherine S Harrison, Daniel Hallatt, Penny J Wozniakiewicz, Mark J Burchell, Luke S Alesbrook, Aishling Dignam, Natasha V Almeida, Caroline L Smith, Brett Clark, Emma R Humphreys-Williams, Paul F Schofield, Luke T Cornwell, Vassilia Spathis, Geraint H Morgan, Mark J Perkins, Richard Kacerek, Peter Campbell-Burns, Francois Colas, Brigitte Zanda, Pierre Vernazza, Sylvain Bouley, Simon Jeanne, Mike Hankey, Gareth S Collins, John S Young, Clive Shaw, Jana Horak, Dave Jones, Nick James, Steve Bosley, Alan Shuttleworth, Paul Dickinson, Ian McMullan, Derek Robson, Andrew R D Smedley, Ben Stanley, Richard Bassom, Mark McIntyre, Adam A Suttle, Richard Fleet, Luc Bastiaens, Míra B Ihász, Sarah McMullan, Sarah J Boazman, Zach I Dickeson, Peter M Grindrod, Annemarie E Pickersgill, Colin J Weir, Fiona M Suttle, Sarah Farrelly, Ieun Spencer, Sheeraz Naqvi, Ben Mayne, Dan Skilton, Dan Kirk, Ann Mounsey, Sally E Mounsey, Sarah Mounsey, Pamela Godfrey, Lachlan Bond, Victoria Bond, Cathryn Wilcock, Hannah Wilcock, Rob Wilcock
Direct links between carbonaceous chondrites and their parent bodies in the solar system are rare. The Winchcombe meteorite is the most accurately recorded carbonaceous chondrite fall. Its pre-atmospheric orbit and cosmic-ray exposure age confirm that it arrived on Earth shortly after ejection from a primitive asteroid. Recovered only hours after falling, the composition of the Winchcombe meteorite is largely unmodified by the terrestrial environment. It contains abundant hydrated silicates formed during fluid-rock reactions, and carbon- and nitrogen-bearing organic matter including soluble protein amino acids...
November 18, 2022: Science Advances
#7
JOURNAL ARTICLE
Rihana S Bokhari, Afshin Beheshti, Sarah E Blutt, Dawn E Bowles, David Brenner, Robert Britton, Lawrence Bronk, Xu Cao, Anushree Chatterjee, Delisa E Clay, Colleen Courtney, Donald T Fox, M Waleed Gaber, Sharon Gerecht, Peter Grabham, David Grosshans, Fada Guan, Erin A Jezuit, David G Kirsch, Zhandong Liu, Mirjana Maletic-Savatic, Kyle M Miller, Ruth A Montague, Prashant Nagpal, Sivan Osenberg, Luke Parkitny, Niles A Pierce, Christopher Porada, Susan M Rosenberg, Paul Sargunas, Sadhana Sharma, Jamie Spangler, Daniel Naveed Tavakol, Dilip Thomas, Gordana Vunjak-Novakovic, Chunbo Wang, Luke Whitcomb, Damian W Young, Dorit Donoviel
Future lunar missions and beyond will require new and innovative approaches to radiation countermeasures. The Translational Research Institute for Space Health (TRISH) is focused on identifying and supporting unique approaches to reduce risks to human health and performance on future missions beyond low Earth orbit. This paper will describe three funded and complementary avenues for reducing the risk to humans from radiation exposure experienced in deep space. The first focus is on identifying new therapeutic targets to reduce the damaging effects of radiation by focusing on high throughput genetic screens in accessible, sometimes called lower, organism models...
November 2022: Life Sciences in Space Research
#8
JOURNAL ARTICLE
Xiaoxiao Wei, Hao Zhang, Tianmei Zou, ZhenLei Wang
As a non-contact and three-dimensional (3D) mirror surface measurement method, stereo-deflectometry has been developing rapidly in recent years. For solving the problem of the measurement of large surface inclination with traditional stereo-deflectometry, 3D stitching of stereo-deflectometry based on marker points is proposed. In this method, the 3D points in the subregions under different perspectives were measured. Meanwhile, the 3D coordinates of the marker points on the sample table, which were calculated by binocular stereo vision, were used for coarse stitching, and the ICP algorithm was used for fine stitching...
September 1, 2022: Applied Optics
#9
JOURNAL ARTICLE
Maryam Zolnoori, Sasha Vergez, Zoran Kostic, Siddhartha Reddy Jonnalagadda, Margaret V McDonald, Kathryn K H Bowles, Maxim Topaz
BACKGROUND: Patients' spontaneous speech can act as a biomarker for identifying pathological entities, such as mental illness. Despite this potential, audio recording patients' spontaneous speech is not part of clinical workflows, and health care organizations often do not have dedicated policies regarding the audio recording of clinical encounters. No previous studies have investigated the best practical approach for integrating audio recording of patient-clinician encounters into clinical workflows, particularly in the home health care (HHC) setting...
May 11, 2022: JMIR Human Factors
#10
JOURNAL ARTICLE
Tomoyuki Akutagawa, Takashi Takeda, Norihisa Hoshino
Dynamic molecular processes, such as short- or long-range proton (H+) and ion (M+) motions, and molecular rotations in electrical conducting and magnetic molecular assemblies enable the fabrication of electron-H+ (or M+) coupling systems, while crystal lattice dynamics and molecular conformation changes in hydrogen-bonded molecular crystals have been utilised in external stimuli responsive reversible gas-induced gate opening and molecular adsorption/desorption behavior. These dynamics of the polar structural units are responsible for the dielectric measurements...
August 9, 2021: Chemical Communications: Chem Comm
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JOURNAL ARTICLE
John H Holmes, James Beinlich, Mary R Boland, Kathryn H Bowles, Yong Chen, Tessa S Cook, George Demiris, Michael Draugelis, Laura Fluharty, Peter E Gabriel, Robert Grundmeier, C William Hanson, Daniel S Herman, Blanca E Himes, Rebecca A Hubbard, Charles E Kahn, Dokyoon Kim, Ross Koppel, Qi Long, Nebojsa Mirkovic, Jeffrey S Morris, Danielle L Mowery, Marylyn D Ritchie, Ryan Urbanowicz, Jason H Moore
BACKGROUND: The electronic health record (EHR) has become increasingly ubiquitous. At the same time, health professionals have been turning to this resource for access to data that is needed for the delivery of health care and for clinical research. There is little doubt that the EHR has made both of these functions easier than earlier days when we relied on paper-based clinical records. Coupled with modern database and data warehouse systems, high-speed networks, and the ability to share clinical data with others are large number of challenges that arguably limit the optimal use of the EHR OBJECTIVES: Our goal was to provide an exhaustive reference for those who use the EHR in clinical and research contexts, but also for health information systems professionals as they design, implement, and maintain EHR systems...
July 19, 2021: Methods of Information in Medicine
#12
JOURNAL ARTICLE
Ru-Jin Li, Jacopo Tessarolo, Haeri Lee, Guido H Clever
It is difficult to assemble multi-component metallo-supramolecular architectures in a non-statistical fashion, which limits their development toward functional materials. Herein, we report a system of interconverting bowls and cages that are able to respond to various selective stimuli (light, ligands, anions), based on the self-assembly of a photochromic dithienylethene (DTE) ligand, L a , with PdII cations. By combining the concept of "coordination sphere engineering", relying on bulky quinoline donors, with reversible photoswitching between the ligand's open ( o - L a ) and closed ( c - L a ) forms, a [Pd2 ( o - L a )4 ] cage ( o - C ) and a [Pd2 ( c - L a )3 ] bowl ( c - B ) were obtained, respectively...
March 5, 2021: Journal of the American Chemical Society
#13
JOURNAL ARTICLE
Courtney Hoge, C Barrett Bowling, S Sam Lim, Cristina Drenkard, Laura Plantinga
OBJECTIVE: To examine the association of income relative to the poverty threshold [poverty income ratio (PIR)] with self-reported physical functioning in a cohort of systemic lupus erythematosus patients. METHODS: We used cross-sectional data on 744 participants from Georgians Organized Against Lupus (GOAL), and secondary analyses used data on 56 participants from a nested pilot study. Primary analyses utilized multivariable linear regression to estimate the association between PIR (categorized as <1...
March 1, 2020: Journal of Rheumatology
#14
JOURNAL ARTICLE
C Sánchez Contreras, J Alcolea, V Bujarrabal, A Castro-Carrizo, L Velilla Prieto, M Santander-García, G Quintana-Lacaci, J Cernicharo
We present continuum and molecular line emission ALMA observations of OH 231.8+4.2, a well studied bipolar nebula around an asymptotic giant branch (AGB) star. The high angular resolution <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mo>(</mml:mo> <mml:mo>∼</mml:mo> <mml:msubsup><mml:mn>0</mml:mn> <mml:mo>·</mml:mo> <mml:mrow><mml:mo>″</mml:mo></mml:mrow> </mml:msubsup> <mml:mn>2</mml:mn> <mml:mtext>-</mml:mtext> <mml:msubsup><mml:mn>0</mml:mn> <mml:mo>·</mml:mo> <mml:mrow><mml:mo>″</mml:mo></mml:mrow> </mml:msubsup> <mml:mn>3</mml:mn> <mml:mo>)</mml:mo></mml:mrow> </mml:math> and sensitivity of our ALMA maps provide the most detailed and accurate description of the overall nebular structure and kinematics of this object to date...
October 23, 2018: Astronomy and Astrophysics
#15
JOURNAL ARTICLE
Alina Kurolap, Orly Eshach Adiv, Tova Hershkovitz, Adi Tabib, Netanel Karbian, Tamar Paperna, Adi Mory, Arcadi Vachyan, Nadav Slijper, Ran Steinberg, Yaniv Zohar, Dror Mevorach, Hagit Baris Feldman
OBJECTIVES: Loss of the complement inhibitor CD55 leads to a syndrome of early-onset protein-losing enteropathy (PLE), associated with intestinal lymphangiectasia and susceptibility to large-vein thrombosis. The in vitro and short-term treatment benefits of eculizumab (C5-inhibitor) therapy for CD55-deficiency have been previously demonstrated. Here we present the 18-months treatment outcomes for 3 CD55-deficiency patients with sustained therapeutic response. METHODS: Three CD55-deficiency patients received off-label eculizumab treatment...
March 2019: Journal of Pediatric Gastroenterology and Nutrition
#16
JOURNAL ARTICLE
Mahendra Khened, Varghese Alex Kollerathu, Ganapathy Krishnamurthi
Deep fully convolutional neural network (FCN) based architectures have shown great potential in medical image segmentation. However, such architectures usually have millions of parameters and inadequate number of training samples leading to over-fitting and poor generalization. In this paper, we present a novel DenseNet based FCN architecture for cardiac segmentation which is parameter and memory efficient. We propose a novel up-sampling path which incorporates long skip and short-cut connections to overcome the feature map explosion in conventional FCN based architectures...
January 2019: Medical Image Analysis
#17
JOURNAL ARTICLE
J S Ross, L M Gay, K Wang, J-A Vergilio, J Suh, S Ramkissoon, H Somerset, J M Johnson, J Russell, S Ali, A B Schrock, D Fabrizio, G Frampton, V Miller, P J Stephens, J A Elvin, D W Bowles
Background: Relapsed/metastatic salivary gland carcinomas (SGCs) have a wide diversity of histologic subtypes associated with variable clinical aggressiveness and response to local and systemic therapies. We queried whether comprehensive genomic profiling could define the tumor subtypes and uncover clinically relevant genomic alterations, revealing new routes to targeted therapies for patients with relapsed and metastatic disease. Patients and methods: From a series of 85 686 clinical cases, DNA was extracted from 40 µm of formalin-fixed paraffin embedded (FFPE) sections for 623 consecutive SGC...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
#18
JOURNAL ARTICLE
Timothy M Bowles, Louise E Jackson, Timothy R Cavagnaro
Climate change will alter both the amount and pattern of precipitation and soil water availability, which will directly affect plant growth and nutrient acquisition, and potentially, ecosystem functions like nutrient cycling and losses as well. Given their role in facilitating plant nutrient acquisition and water stress resistance, arbuscular mycorrhizal (AM) fungi may modulate the effects of changing water availability on plants and ecosystem functions. The well-characterized mycorrhizal tomato (Solanum lycopersicum L...
January 2018: Global Change Biology
#19
JOURNAL ARTICLE
Xinyu Li, Dandan Sun, Xu Li, Dashuai Zhu, Zhenzhen Jia, Jiajia Jiao, Kai Wang, Deling Kong, Xin Zhao, Lin Xu, Qiang Zhao, Dongyan Chen, Xizeng Feng
Carbon nanomaterials have been used to treat neurodegenerative diseases and neural disorders due to their diverse molecular structures. Corannulene is a three-dimensional π-bowl carbon nanomaterial that is different from planar PAHs, fullerenes and carbon nanotubes, but little is known about its biological functions. Herein, corannulene was functionalized with mPEG-DESP to prepare PEGylation corannulene nanoparticles (PEGylation CoNps). The synthesized PEGylation CoNps shows enhanced solubility and reduced aggregation when compared corannulene...
March 28, 2017: Biomaterials Science
#20
JOURNAL ARTICLE
Laura Plantinga, S Sam Lim, C Barrett Bowling, Cristina Drenkard
OBJECTIVE: To examine whether older age was associated with lower health-related quality of life (HRQOL) among patients with systemic lupus erythematosus (SLE) and whether differential disease-related damage and activity explained these associations. METHODS: We used cross-sectional data on 684 patients with SLE aged ≥20 years from the Georgians Organized Against Lupus cohort to estimate the associations between age (categorised as 20-39, 40-59 and ≥60 years) and HRQOL (Short Form-12 norm-based domain and physical component summary (PCS) and mental component summary (MCS) scores), using multivariable linear regression...
2016: Lupus Science & Medicine
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