Misty M Strain, Nicholas J Conley, Lily S Kauffman, Liliana Espinoza, Stephanie Fedorchak, Patricia Castro Martinez, Maisie E Crook, Maira Jalil, Georgia E Hodes, Stephen B G Abbott, Ali D Güler, John N Campbell, Carie R Boychuk
Cardiovagal neurons (CVNs) innervate cardiac ganglia through the vagus nerve to control cardiac function. Although the cardioinhibitory role of CVNs in nucleus ambiguus (CVN NA ) is well established, the nature and functionality of CVNs in dorsal motor nucleus of the vagus (CVN DMV ) is less clear. We therefore aimed to characterize CVN DMV anatomically, physiologically, and functionally. Optogenetically activating cholinergic DMV neurons resulted in robust bradycardia through peripheral muscarinic (parasympathetic) and nicotinic (ganglionic) acetylcholine receptors, but not beta-1-adrenergic (sympathetic) receptors...
November 16, 2023: bioRxiv