Yufan Wu, Yinglin Guo, Tairun Huang, Dehao Huang, Li Liu, Chunyan Shen, Cuiping Jiang, Zhuxian Wang, Hongkai Chen, Peiyi Liang, Yi Hu, Zeying Zheng, Tao Liang, Dan Zhai, Hongxia Zhu, Qiang Liu
Licorice flavonoid (LF) is the main component of Glycyrrhizae Radix et Rhizoma, a "medicine food homology" herbal medicine, which has anti-digestive ulcer activity, but the mechanism in anti-gastric ulcer (GU) remains to be elucidated. In this study, we manifested that LF increased the viability of human gastric mucosal epithelial (GES-1) cells, attenuated ethanol (EtOH)-induced manifestations, reduced histological injury, suppressed inflammation, and restored gastric mucosal barrier in GU rats. After LF therapy, the EtOH-induced gut dysbiosis was partly modulated, and short-chain fatty acids (SCFAs) like butyric acid, propionic acid, and valeric acid were found in higher concentrations...
November 10, 2023: Biomedicine & Pharmacotherapy