Hugo Alves-Figueiredo, Christian Silva-Platas, Manuel Estrada, Yuriana Oropeza-Almazán, Martin Ramos-González, Judith Bernal-Ramírez, Eduardo Vázquez-Garza, Armando Tellez, Felipe Salazar-Ramírez, Abraham Méndez-Fernández, José Luis Galaz, Pedro Lobos, Keith Youker, Omar Lozano, Guillermo Torre-Amione, Gerardo García-Rivas
The role of the mitochondrial calcium uniporter (MCU) in energy dysfunction and hypertrophy in heart failure (HF) remains unknown. In angiotensin II (ANGII)-induced hypertrophic cardiac cells we have shown that hypertrophic cells overexpress MCU and present bioenergetic dysfunction. However, by silencing MCU, cell hypertrophy and mitochondrial dysfunction are prevented by blocking mitochondrial calcium overload, increase mitochondrial reactive oxygen species, and activation of nuclear factor kappa B-dependent hypertrophic and proinflammatory signaling...
April 2024: JACC. Basic to Translational Science