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REVIEW
Divya Seth, Deepak Kamat
Wheezing is a high pitched, whistling sound generated when air flows through narrowed airways and is often equated with asthma. However, wheezing may be a presenting symptom of various other conditions including structural lesions of the airways, foreign body aspiration, pulmonary infections as well as cardiac causes. Underlying etiology of wheezing may also vary with age. Detailed history, physical examination, and laboratory investigations are often required to identify the underlying etiology of wheezing...
May 2024: Pediatric Annals
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JOURNAL ARTICLE
Sandeep Kumar, Arun Sharma, Kuruswamy Thurai Prasad, Inderpaul S Sehgal, Sahajal Dhooria, Ritesh Agarwal, Valliappan Muthu
No abstract text is available yet for this article.
March 1, 2024: Lung India: Official Organ of Indian Chest Society
#3
JOURNAL ARTICLE
Sonia Ares-Gómez, Narmeen Mallah, Jacobo Pardo-Seco, Alberto Malvar-Pintos, Olaia Pérez-Martínez, María-Teresa Otero-Barrós, Nuria Súarez-Gaiche, Maria-Isolina Santiago-Pérez, Juan-Manuel González-Pérez, Luis-Ricardo López-Pérez, Benigno Rosón, Rosa-María Alvárez-Gil, Olga-María Ces-Ozores, Victoria Nartallo-Penas, Susana Mirás-Carballal, Carmen Rodríguez-Tenreiro, Irene Rivero-Calle, Antonio Salas, Carmen Durán-Parrondo, Federico Martinón-Torres
BACKGROUND: The morbidity burden of respiratory syncytial virus (RSV) in infants extends beyond hospitalization. Defining the RSV burden before implementing prophylaxis programs is essential for evaluating any potential impact on short- to mid-term morbidity and the utilization of primary healthcare (PHC) and emergency services (ES). We established this reference data using a population-based cohort approach. METHODS: Infants hospitalized for RSV from January 2016 to March 2023 were matched with non-hospitalized ones based on birthdate and sex...
May 2024: Pediatric Allergy and Immunology
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JOURNAL ARTICLE
Kathryn J Britton, William Pomat, Joycelyn Sapura, John Kave, Birunu Nivio, Rebecca Ford, Wendy Kirarock, Hannah C Moore, Lea-Ann Kirkham, Peter C Richmond, Jocelyn Chan, Deborah Lehmann, Fiona M Russell, Christopher C Blyth
BACKGROUND: Pneumonia is the leading cause of death in young children globally and is prevalent in the Papua New Guinea highlands. We investigated clinical predictors of hypoxic pneumonia to inform local treatment guidelines in this resource-limited setting. METHODS: Between 2013 and 2020, two consecutive prospective observational studies were undertaken enrolling children 0-4 years presenting with pneumonia to health-care facilities in Goroka Town, Eastern Highlands Province...
April 2024: The Lancet Regional Health. Western Pacific
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JOURNAL ARTICLE
Raquel Granell, Sadia Haider, Matea Deliu, Anhar Ullah, Osama Mahmoud, Sara Fontanella, Lesley Lowe, Angela Simpson, James William Dodd, Seyed Hasan Arshad, Clare S Murray, Graham Roberts, Alun Hughes, Chloe Park, John W Holloway, Adnan Custovic
RATIONALE: Lung function in early adulthood is associated with subsequent adverse health outcomes. OBJECTIVES: To ascertain whether stable and reproducible lung function trajectories can be derived in different populations and investigate their association with objective measures of cardiovascular structure and function. METHODS: Using latent profile modelling, we studied three population-based birth cohorts with repeat spirometry data from childhood into early adulthood to identify trajectories of forced expiratory volume in 1 s (FEV1 )/forced vital capacity (FVC)...
May 2, 2024: Thorax
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JOURNAL ARTICLE
Ann R Falsey, Edward E Walsh, Stacey L House, Yannick Vandendijck, Marita Stevens, Eric K H Chan, Gabriela Ispas
BACKGROUND: Influenza, respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) are common respiratory viruses causing similar symptoms. Optimal tools to assess illness severity for these viruses have not been defined. Using the Hospitalized Acute Respiratory Tract Infection (HARTI) study data, we report symptom severity by clinician-rated clinical severity scores (CSS) in adults with influenza, RSV, or hMPV and correlations between CSS and patient-reported outcomes (PROs)...
May 2024: Influenza and Other Respiratory Viruses
#7
JOURNAL ARTICLE
Matthew S Perzanowski, Virginia Rauh, Bruce Ramphal, Luis Acosta, Lori Hoepner, Andrew G Rundle, Frederica P Perera, Julie Herbstman, Rachel L Miller, Amy E Margolis
Increased parasympathetic nervous system (PNS) activity is associated with attention-deficit/hyperactivity disorder (ADHD) inattentive symptoms, but not hyperactive-impulsive symptoms, and may contribute to inattentive subtype etiology. Guided by prior work linking infant rhinorrhea and watery eyes without a cold (RWWC) to PNS dysregulation, we examined associations between infant RWWC and childhood ADHD symptoms in a longitudinal cohort of Black and Latinx children living in the context of economic disadvantage (N = 301 youth: 158 females, 143 males)...
July 2024: Developmental Psychobiology
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JOURNAL ARTICLE
Wangquan Ji, Yu Chen, Shujie Han, Bowen Dai, Kang Li, Shuang Li, Zijie Li, Shouhang Chen, Yaodong Zhang, Xiaolong Zhang, Xiaolong Li, Qingmei Wang, Jiaying Zheng, Chenyu Wang, Qiujing Liang, Shujuan Han, Ruyu Zhang, Fang Wang, Yuefei Jin
BACKGROUND: In the aftermath of the COVID-19 pandemic, there has been a surge in human metapneumovirus (HMPV) transmission, surpassing pre-epidemic levels. We aim to elucidate the clinical and epidemiological characteristics of HMPV infections in the post-COVID-19 pandemic era. METHODS: In this retrospective single-center study, participants diagnosed with laboratory confirmed HMPV infection through Targeted Next Generation Sequencing were included. The study encompassed individuals admitted to Henan Children's Hospital between April 29 and June 5, 2023...
April 30, 2024: Virology Journal
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JOURNAL ARTICLE
Shuhui Dai, Judith Wellens, Nan Yang, Doudou Li, Jingjing Wang, Lijuan Wang, Shuai Yuan, Yazhou He, Peige Song, Ron Munger, Monique Potvin Kent, Amanda J MacFarlane, Patrick Mullie, Susan Duthie, Julian Little, Evropi Theodoratou, Xue Li
BACKGROUND & AIMS: Ultra-processed food (UPF) intake has increased sharply over the last few decades and has been consistently asserted to be implicated in the development of non-communicable diseases. We aimed to evaluate and update the existing observational evidence for associations between ultra-processed food (UPF) consumption and human health. METHODS: We searched Medline and Embase from inception to March 2023 to identify and update meta-analyses of observational studies examining the associations between UPF consumption, as defined by the NOVA classification, and a wide spectrum of health outcomes...
April 18, 2024: Clinical Nutrition
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JOURNAL ARTICLE
Zhuxia Li, Xinxing Zhang, Huiquan Sun, Chuangli Hao, Xuejun Shao, Jun Xu, Xin Zhang, Yuqing Wang
OBJECTIVE: The aim of this study is to investigate the clinical characteristics and pathogens involved in persistent or recurrent pneumonia combined with airway malacia in children. METHODS: We retrospectively reviewed the information of children hospitalised with persistent or recurrent pneumonia, including clinical presentations, laboratory examination results and pathogens. RESULTS: A total of 554 patients were admitted, 285 (51.44%) of whom were found to have airway malacia...
May 2024: Clinical Respiratory Journal
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JOURNAL ARTICLE
Chuhan Cheng, Jing Lin, Zihan Zhang, Liyan Zhang
BACKGROUND: Asthma, characterized by recurrent wheezing, breathlessness, chest tightness, and coughing, is a major health concern among children and adolescents worldwide, currently affecting more than 5 million children. The increasing prevalence of obesity and overweight among the pediatric population has made the issue of childhood respiratory health more complex. Compared with children of healthy weight, the risk of asthma is higher in overweight and obese children. Zinc, a nutrient that regulates the oxidant-antioxidant balance, has been studied for its potential protective effects against asthma in adults and children...
May 2024: World Allergy Organization Journal
#12
JOURNAL ARTICLE
Maria V Dimou, Paraskevi Xepapadaki, John Lakoumentas, Leonardos Mageiros, Xenophon Aggelidis, Maria Antonopoulou, Petros Bakakos, Sophia Βotskariova, Konstantinos Chliveros, Spyridon Chrysoulakis, Dionysios Dimas, Nikolaos Douladiris, Mina Gaga, Christos Grigoreas, Lampros Kalogiros, Michael Katotomichelakis, Evangelia Kompoti, Jannis Constantinidis, Zoi Koutsogianni, Stelios Loukides, Michael Makris, Emmanouil Manousakis, Pavlos Marangoudakis, Maria Marmara, Nikolaos Mikos, Paraskevi Mitsakou, Dimitrios Mitsias, Aris Pagalos, Vasilios Papanikolaou, Ioannis Paraskevopoulos, Constantinos Pitsios, Fotis Psarros, Nikoletta Rovina, Konstantinos Samitas, Evaggelia Stefanaki, Mina Vallianatou, Dimitrios Vourdas, Ioanna Tsiligianni, Jean Bousquet, Nikolaos G Papadopoulos
BACKGROUND: Allergic rhinitis (AR) is a common respiratory disease encompassing a variety of phenotypes. Patients can be sensitized to one or more allergens. There are indications that polysensitization is associated with more severe disease. However, the extent to which the level of sensitization is associated to clinical disease variability, underlying the distinct nature of AR from AR+ conjunctivitis or AR+ asthma, is not known. OBJECTIVE: The aim of this study was to evaluate phenotypical differences between mono- and poly-sensitized patients with AR and to quantify their symptomatic variability...
April 26, 2024: Annals of Allergy, Asthma & Immunology
#13
JOURNAL ARTICLE
Airin Veronese, Tina Uršič, Simona Bizjak Vojinovič, Jasna Rodman Berlot
Human metapneumovirus (hMPV) is an important pathogen that causes both upper (URTIs) and lower respiratory tract infections (LRTIs) in children. The virus can be implicated in severe bronchiolitis and pneumonia, necessitating hospitalization, with certain cases requiring intensive care unit intervention. As part of a retrospective observational study, we aimed to identify indicators of severe hMPV respiratory tract infections in children referred to the University Children's Hospital Ljubljana and the Department of Infectious Diseases Ljubljana, Slovenia, during a recent outbreak...
March 23, 2024: Microorganisms
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JOURNAL ARTICLE
Rodney Mudau, Kuku Voyi, Joyce Shirinde
BACKGROUND: This study aimed to investigate the prevalence of wheezing and its association with environmental tobacco smoke exposure among rural and urban preschool children in Mpumalanga province, South Africa, an area associated with poor air quality. METHODS: In this study, parents/caregivers of preschool children ( n = 3145) completed a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Data were analysed using multiple logistic regression models...
April 11, 2024: International Journal of Environmental Research and Public Health
#15
JOURNAL ARTICLE
Elizabeth Kicic-Starcevich, David G Hancock, Thomas Iosifidis, Patricia Agudelo-Romero, Jose A Caparros-Martin, Yuliya V Karpievitch, Desiree Silva, Lidija Turkovic, Peter N Le Souef, Anthony Bosco, David J Martino, Anthony Kicic, Susan L Prescott, Stephen M Stick
INTRODUCTION: Recurrent wheezing disorders including asthma are complex and heterogeneous diseases that affect up to 30% of all children, contributing to a major burden on children, their families, and global healthcare systems. It is now recognized that a dysfunctional airway epithelium plays a central role in the pathogenesis of recurrent wheeze, although the underlying mechanisms are still not fully understood. This prospective birth cohort aims to bridge this knowledge gap by investigating the influence of intrinsic epithelial dysfunction on the risk for developing respiratory disorders and the modulation of this risk by maternal morbidities, in utero exposures, and respiratory exposures in the first year of life...
2024: Front Allergy
#16
JOURNAL ARTICLE
Eline Lauwers, Toon Stas, Ian McLane, Annemiek Snoeckx, Kim Van Hoorenbeeck, Wilfried De Backer, Kris Ides, Jan Steckel, Stijn Verhulst
BACKGROUND: Computer Aided Lung Sound Analysis (CALSA) aims to overcome limitations associated with standard lung auscultation by removing the subjective component and allowing quantification of sound characteristics. In this proof-of-concept study, a novel automated approach was evaluated in real patient data by comparing lung sound characteristics to structural and functional imaging biomarkers. METHODS: Patients with cystic fibrosis (CF) aged > 5y were recruited in a prospective cross-sectional study...
April 24, 2024: Respiratory Research
#17
JOURNAL ARTICLE
Wei Wang, Lu Wang, Zhaoqing Yin, Shujuan Zeng, Guohua Yao, Yuqiao Liu, Yulian Fang, Cuian Ma, Hualei Cui
INTRODUCTION: This study aimed to investigate the correlation between Mycoplasma pneumoniae (MP) - DNA load in the bronchoalveolar lavage fluid (BALF) of children with MP pneumonia (MPP) and its subtypes, relevant laboratory data, imaging, extrapulmonary complications in infected children, and its clinical significance in evaluating the disease. METHODS: Children hospitalized with MPP at Tianjin Children's Hospital between December 2017 and December 2020 were selected for the study, excluding those with mixed viral, bacterial, and fungal infections...
2024: Frontiers in Pediatrics
#18
JOURNAL ARTICLE
Yingfeng Lu, Qinghui Chen, Shaolong Ren, Youyi Zhang, Liping Yi, Chen Qian, Jiaming Shen, Xiaofei Liu, Miao Jiang, Biying Wang, Jian Song, Xuejun Shao, Tao Zhang, Jianmei Tian, Genming Zhao
BACKGROUND: Nonpharmaceutical interventions (NPIs) targeted at SARS-CoV-2 have remarkably affected the circulation of other respiratory pathogens, including respiratory syncytial virus (RSV). This study aimed to assess the changes in epidemiological and clinical characteristics of RSV infections in hospitalized children before and during the pandemic in Suzhou, China. METHODS: We prospectively enrolled children aged < 18 years who were hospitalized in Soochow University Affiliated Children's Hospital with acute lower respiratory infection (ALRIs) from January 2018 to July 2022...
April 2024: Influenza and Other Respiratory Viruses
#19
JOURNAL ARTICLE
Shaun O' Hagan, Hannah Norman-Bruce, Michael Shields, Helen Elizabeth Groves
No abstract text is available yet for this article.
April 22, 2024: Archives of Disease in Childhood
#20
JOURNAL ARTICLE
Gilda Zarate-Gonzalez, Paul Brown, Ricardo Cisneros
INTRODUCTION: The San Joaquin Valley (SJV) is often recognized as one of the most polluted regions in the US. Periods of pollution exposure are associated with increased health burden related to respiratory inflammation and undermined lung function, which aggravates respiratory diseases such as asthma and leads to symptoms such as coughing, wheezing, or difficulty breathing. Asthma costs US$ 82 billion annually in healthcare costs, missed work and school in the US. METHODS: Employing a societal perspective, a cost of illness design was combined with environmental epidemiological methods to analyze the economic impact of O3 , NO2 , and PM2...
2024: Journal of Asthma and Allergy
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