keyword
https://read.qxmd.com/read/38702436/predicting-the-risk-of-pancreatic-cancer-in-adults-with-new-onset-diabetes-development-and-internal-external-validation-of-a-clinical-risk-prediction-model
#1
JOURNAL ARTICLE
Ash Kieran Clift, Pui San Tan, Martina Patone, Weiqi Liao, Carol Coupland, Rachael Bashford-Rogers, Shivan Sivakumar, Julia Hippisley-Cox
BACKGROUND: The National Institute for Health and Care Excellence (NICE) recommends that people aged 60+ years with newly diagnosed diabetes and weight loss undergo abdominal imaging to assess for pancreatic cancer. More nuanced stratification could lead to enrichment of these referral pathways. METHODS: Population-based cohort study of adults aged 30-85 years at type 2 diabetes diagnosis (2010-2021) using the QResearch primary care database in England linked to secondary care data, the national cancer registry and mortality registers...
May 3, 2024: British Journal of Cancer
https://read.qxmd.com/read/38695109/macrophage-and-neutrophil-dysregulation-in-diabetic-wounds
#2
JOURNAL ARTICLE
Shannon M Clayton, Sasha H Shafikhani, Athena M Soulika
SIGNIFICANCE: The incidence of diabetes continues to rise throughout the world in an alarming rate. Diabetic patients often develop diabetic foot ulcers (DFUs), many of which do not heal. Non-healing DFUs are a major cause of hospitalization, amputation, and increased morbidity. Understanding the underlying mechanisms of impaired healing in DFU is crucial for its management. RECENT ADVANCES: This review focuses on the recent advancements in macrophage and neutrophils in diabetic wounds and DFUs...
May 2, 2024: Advances in Wound Care
https://read.qxmd.com/read/38693745/cellular-and-molecular-mechanisms-of-neuronal-degeneration-in-early-stage-diabetic-retinopathy
#3
JOURNAL ARTICLE
Andrew Callan, Sonal Jha, Laura Valdez, Andrew Tsin
BACKGROUND: Studies on the early retinal changes in Diabetic Retinopathy (DR) have demonstrated that neurodegeneration precedes vascular abnormalities like microaneurysms or intraretinal hemorrhages. Therefore, there is a growing field of study to analyze the cellular and molecular pathways involved to allow for the development of novel therapeutics to prevent the onset or delay the progression of DR. Molecular Mechanisms: Oxidative stress and mitochondrial dysfunction contribute to neurodegeneration through pathways involving polyol, hexosamine, advanced glycation end products, and protein kinase C...
April 30, 2024: Current Vascular Pharmacology
https://read.qxmd.com/read/38692717/cost-analysis-for-initiating-an-integrated-package-of-essential-non-communicable-disease-interventions-pen-plus-in-kondoa-district-hospital-tanzania-a-time-driven-activity-based-costing-tdabc-study-protocol
#4
JOURNAL ARTICLE
Harrieth Peter Ndumwa, Amani Thomas Mori, George Mugambage Ruhago, Ritha Willilo, Ryan McBain, Chantelle Boudreaux, Emily Wroe, Alma J Adler, Gene Bukhman, Mary Theodory Mayige, Oddvar Kaarboe
INTRODUCTION: Non-communicable diseases (NCDs) constitute approximately 74% of global mortality, with 77% of these deaths occurring in low-income and middle-income countries. Tanzania exemplifies this situation, as the percentage of total disability-adjusted life years attributed to NCDs has doubled over the past 30 years, from 18% to 36%. To mitigate the escalating burden of severe NCDs, the Tanzanian government, in collaboration with local and international partners, seeks to extend the integrated package of essential interventions for severe NCDs (PEN-Plus) to district-level facilities, thereby improving accessibility...
May 1, 2024: BMJ Open
https://read.qxmd.com/read/38689612/home-blood-pressure-measurement-self-reporting-in-real-life-practices-using-the-hy-result-app-self-monitoring-and-digital-pathway
#5
JOURNAL ARTICLE
Nicolas Postel-Vinay, Nicole Gebara, Roland Asmar, Dominique Stephan, Aurelien Lorthioir, Laurence Amar
BACKGROUND: Little real-life information is available on the clinical characteristics of information and communication technologies (ICTs) users, particularly in the context of hypertension and home blood pressure measurement (HBPM). This retrospective observational study describes HBPM practices obtained through the Hy-Result® system, a validated app designed to help patients perform HBPM and understand their results through an automatic interpretation of the readings using web interface...
2024: MHealth
https://read.qxmd.com/read/38686257/from-sugar-spikes-to-pressure-peaks-navigating-the-world-of-diabetes-hypertension-obesity-and-kidney-health
#6
REVIEW
Nay Phone Hlyan, Talha Arif, Saina S Jaufar, Abdur Rehman, Biruk D Ayalew, Biniyam J Batu, Muhidin I Hundesa, May Su Hlaing, Hamza Islam, Rabia Islam, Abdullah Shehryar, Maria Quinn
Diabetes, hypertension, obesity, and chronic kidney disease (CKD) are major public health challenges globally, contributing significantly to morbidity and mortality. The co-occurrence and interplay among these conditions exacerbate health outcomes, highlighting the need for an integrated understanding and approach to management. This narrative review aims to explore the complex relationships between diabetes, hypertension, obesity, and CKD, elucidating their collective impact on health. It discusses the epidemiological trends, underlying pathophysiological mechanisms, genetic predispositions, current treatment strategies, and the future direction of research and therapy...
March 2024: Curēus
https://read.qxmd.com/read/38656782/exploring-the-pathways-of-diabetes-foot-complications-treatment-and-investigating-experiences-from-frontline-health-care-professionals-protocol-for-a-mixed-methods-study
#7
JOURNAL ARTICLE
Elisavet Andrikopoulou, Panagiotis Chatzistergos, Nachiappan Chockalingam
BACKGROUND: Diabetes affects more than 4.3 million individuals in the United Kingdom, with 19% to 34% developing diabetes-related foot ulceration (DFU) during their lifespan, which can lead to an amputation. In the United Kingdom, every week, approximately 169 people have an amputation due to diabetes. Preventing first-ever ulcers is the most effective strategy to reduce the occurrence of diabetes-related amputations, but research in this space is lacking. OBJECTIVE: This protocol seeks to document the experiences and perspectives of frontline health care professionals who work with people who have diabetes and diabetes-related foot problems...
April 24, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38649470/complications-and-visual-outcomes-following-surgical-resection-of-pediatric-optic-pathway-hypothalamic-gliomas-a-systematic-review-and-meta-analysis
#8
REVIEW
Ibrahem Albalkhi, Areez Shafqat, Othman Bin-Alamer, Arka N Mallela, Zachary C Gersey, David Fernandes Cabral, Abdulrahman J Sabbagh, Constantinos G Hadjipanayis, Jorge A González-Martínez, Robert M Friedlander, Hussam Abou-Al-Shaar
Pediatric optic pathway/hypothalamic gliomas (OPHG) pose challenges in treatment due to their location and proximity to vital structures. Surgical resection plays a key role in the management of OPHG especially when the tumor exhibits mass effect and causes symptoms. However, data regarding outcomes and complications of surgical resection for OPHG remains heterogenous. The authors performed a systematic review on pediatric OPHG in four databases: PubMed, EMBASE, Cochrane Library, and Google Scholar. We included studies that reported on the visual outcomes and complications of OPHG resection...
April 23, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38645405/integrating-electronic-health-records-and-polygenic-risk-to-identify-genetically-unrelated-comorbidities-of-schizophrenia-that-may-be-modifiable
#9
JOURNAL ARTICLE
Tess Vessels, Nicholas Strayer, Hyunjoon Lee, Karmel W Choi, Siwei Zhang, Lide Han, Theodore J Morley, Jordan W Smoller, Yaomin Xu, Douglas M Ruderfer
BACKGROUND: Patients with schizophrenia have substantial comorbidity that contributes to reduced life expectancy of 10 to 20 years. Identifying modifiable comorbidities could improve rates of premature mortality. Conditions that frequently co-occur but lack shared genetic risk with schizophrenia are more likely to be products of treatment, behavior, or environmental factors and therefore are enriched for potentially modifiable associations. METHODS: Phenome-wide comorbidity was calculated from electronic health records of 250,000 patients across 2 independent health care institutions (Vanderbilt University Medical Center and Mass General Brigham); associations with schizophrenia polygenic risk scores were calculated across the same phenotypes in linked biobanks...
May 2024: Biol Psychiatry Glob Open Sci
https://read.qxmd.com/read/38643081/developing-an-interprofessional-decision-support-tool-for-diabetic-foot-ulcers-management-in-primary-care-within-the-family-medicine-group-model-a-delphi-study-in-canada
#10
JOURNAL ARTICLE
Magali Brousseau-Foley, Virginie Blanchette, Julie Houle, François Trudeau
BACKGROUND: Primary care professionals encounter difficulties coordinating the continuum of care between primary care providers and second-line specialists and adhere to practice guidelines pertaining to diabetic foot ulcers management. Family medicine groups are providing primary care services aimed to improve access, interdisciplinary care, coordination and quality of health services, and reduce emergency department visits. Most professionals working in family medicine groups are primary care physicians and registered nurses...
April 20, 2024: BMC Prim Care
https://read.qxmd.com/read/38634543/an-enhanced-postpartum-transition-program-to-primary-care
#11
JOURNAL ARTICLE
Natalie A Cameron, Heather Birdsell, Charlotte M Niznik, Ruth Michon, Emily Donelan, Lynn M Yee, Brigid M Dolan
Background: Gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) are risk factors for future cardiovascular disease, yet few individuals receive postpartum care with primary care clinicians (PCP). To facilitate transitions of care to PCPs and improve cardiovascular health monitoring within the first 13 months postpartum, we developed and piloted an enhanced postpartum referral pathway for patients with GDM or HDP. Methods: Eligible patients included those who received perinatal care at a large, urban, academic medical center, experienced GDM or HDP during their most recent pregnancy, and lacked an existing PCP...
April 18, 2024: Journal of Women's Health
https://read.qxmd.com/read/38605789/effect-of-a-two-only-meals-a-day-and-exercise-lifestyle-on-hba1c-and-anti-diabetic-medication-in-a-follow-up-study-of-subjects-with-type-2-diabetes-attending-a-free-clinic-in-a-north-maharashtra-city
#12
JOURNAL ARTICLE
Shyam V Ashtekar, Ratna S Ashtekar, Pradeep R Deshmukh, Jagdish D Powar
BACKGROUND: Type 2 Diabetes (T2D) is a global challenge with rising prevalence, inadequate compliance, and poor outcomes. AIMS: Assess the effect of a 2-only-daily-meals with exercise lifestyle (2-OMEX) on (a) HbA1c, (b) anti-diabetic medication count (ADMC), (c) Kcal intakes, body weight, fasting insulin, and subjective well-being. MATERIALS AND METHODS: This is a single-arm follow-up study conducted in a free 2-OMEX clinic in 2019-2020. Information for two meals and exercise compliance was obtained during the clinic visit...
February 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38599488/mobility-rates-after-lower-limp-amputation-for-patients-treated-with-physician-led-collaborative-care-model
#13
JOURNAL ARTICLE
Allison McGinnis, Zach Weber, Bara Zuhaili, H Edward Garrett
OBJECTIVE: Clinical outcomes after major lower limb amputation have been historically poor. The current care provided to most amputees is often disorganized and without physician supervision. The primary purpose of this study is to examine rates of post-amputation mobility achieved with a prosthesis by patients with chronic limb-threatening ischemia (CLTI) and/or diabetes who required major lower limb amputation and were treated under an established physician-led collaborative care pathway...
April 8, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38594149/identification-influencing-factors-and-outcomes-of-time-delays-in-the-management-pathway-of-diabetic-foot-a-systematic-review
#14
REVIEW
Li Lingyan, Xu Liwei, Zhao Han, Tang Xin, He Bingyang, Ma Yuanyuan, Qin Peiwei, Ma Peifen
OBJECTIVE: A systematic review was conducted to evaluate the time delays in the management of diabetic foot and explore influencing factors of these delays and potential outcomes. METHODS: The researchers searched several electronic databases (Pubmed, Web of Science, Cochrane Library, EMbase, CNKI, WanFang, CBM and VIP) for English and Chinese studies that examined time delays in the management pathway of diabetic foot. Two authors independently screened and extracted data, and assessed the quality of the included studies using the Newcastle-Ottawa Scale and the Agency for Health Research and Quality checklist...
April 5, 2024: Journal of Tissue Viability
https://read.qxmd.com/read/38590481/the-role-of-telemedicine-in-enhancing-chronic-kidney-disease-ckd-management-and-dialysis-care
#15
EDITORIAL
Ramchandani Santosh, Yaqub Nadeem Mohammed, Zubair Rahaman, Sakshi Khurana
Telemedicine has emerged as a transformative solution in the realm of healthcare, particularly in addressing the complexities and challenges associated with chronic kidney disease (CKD) and dialysis care. This editorial explores the potential of telemedicine in revolutionizing the management and treatment of kidney diseases, highlighting its role in mitigating the burdens faced by healthcare systems worldwide. With the advent of high-quality audio and visual platforms, telemedicine has facilitated remote healthcare delivery, enabling healthcare professionals to provide exceptional care from a distance...
March 2024: Curēus
https://read.qxmd.com/read/38584181/can-the-introduction-of-a-12-lead-ecg-help-reduce-mortality-in-those-presenting-with-foot-ulceration-to-multidisciplinary-diabetic-foot-clinics-an-observational-evaluation-of-a-real-world-implementation-pilot-in-england
#16
JOURNAL ARTICLE
Jonathan Valabhji, Naomi Holman, Nicholas Collins, Robert J Young, Paul Chadwick, Adam Robinson, Rahul Nayar, Satyan Rajbhandari, David V Coppini, Marie-France Kong, Simon Ashwell, Ananth Nayak, Sanjeev Mehta, Chris Manu, Michael Edmonds, Catherine Gooday, Ketan Dhatariya
AIMS/HYPOTHESIS: The risk of dying within 2 years of presentation with diabetic foot ulceration is over six times the risk of amputation, with CVD the major contributor. Using an observational evaluation of a real-world implementation pilot, we aimed to assess whether for those presenting with diabetic foot ulceration in England, introducing a 12-lead ECG into routine care followed by appropriate clinical action was associated with reduced mortality. METHODS: Between July 2014 and December 2017, ten multidisciplinary diabetic foot services in England participated in a pilot project introducing 12-lead ECGs for new attendees with foot ulceration...
April 8, 2024: Diabetologia
https://read.qxmd.com/read/38582367/accelerated-closure-of-diabetic-wounds-by-efficient-recruitment-of-fibroblasts-upon-inhibiting-a-14-3-3-rock-regulatory-axis
#17
JOURNAL ARTICLE
M Zahied Johan, Natasha T Pyne, Natasha Kolesnikoff, Valentina Poltavets, Zahra Esmaeili, Joanna M Woodcock, Angel F Lopez, Allison J Cowin, Stuart M Pitson, Michael S Samuel
Chronic non-healing wounds negatively impact on quality of life and are a significant financial drain on health systems. The risk of infection that exacerbates co-morbidities in patients necessitates regular application of wound care. Understanding mechanisms underlying impaired wound healing are therefore a key priority to inform effective new generation treatments. Here, we demonstrate that 14-3-3-mediated suppression of signaling through ROCK is a critical mechanism that inhibits the healing of diabetic wounds...
April 4, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38579965/genetic-determinants-of-vascular-dementia
#18
REVIEW
Nazia Pathan, Muskaan Kaur Kharod, Sajjha Nawab, Matteo Di Scipio, Guillaume Paré, Michael Chong
Vascular dementia (VaD) is a prevalent form of cognitive impairment with underlying vascular etiology. In this review, we examine recent genetic advancements in our understanding of VaD, encompassing a range of methodologies including genome-wide association studies (GWAS), polygenic risk scores (PRS), heritability estimates, and family studies for monogenic disorders revealing the complex and heterogeneous nature of the disease. We report well-known genetic associations and highlight potential pathways and mechanisms implicated in VaD and its pathological risk factors, including stroke, cerebral small vessel diseases and cerebral amyloid angiopathy...
April 3, 2024: Canadian Journal of Cardiology
https://read.qxmd.com/read/38578397/sglt2-inhibitors%C3%A2-the-new-standard-of-care-for-cardiovascular-renal-and-metabolic-protection-in-type-2-diabetes-a-narrative-review
#19
REVIEW
Samuel Seidu, Vicki Alabraba, Sarah Davies, Philip Newland-Jones, Kevin Fernando, Stephen C Bain, Jane Diggle, Marc Evans, June James, Naresh Kanumilli, Nicola Milne, Adie Viljoen, David C Wheeler, John P H Wilding
A substantial evidence base supports the use of sodium-glucose cotransporter-2 inhibitors (SGLT2is) in the treatment of type 2 diabetes mellitus (T2DM). This class of medicines has demonstrated important benefits that extend beyond glucose-lowering efficacy to protective mechanisms capable of slowing or preventing the onset of long-term cardiovascular, renal and metabolic (CVRM) complications, making their use highly applicable for organ protection and the maintenance of long-term health outcomes. SGLT2is have shown cost-effectiveness in T2DM management and economic savings over other glucose-lowering therapies due to reduced incidence of cardiovascular and renal events...
April 5, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38575153/characterization-of-the-zebrafish-as-a-model-of-atp-sensitive-potassium-channel-hyperinsulinism
#20
JOURNAL ARTICLE
Christine A Juliana, Joshua Benjet, Diva D De Leon
INTRODUCTION: Congenital hyperinsulinism (HI) is the leading cause of persistent hypoglycemia in infants. Current models to study the most common and severe form of HI resulting from inactivating mutations in the ATP-sensitive potassium channel (KATP ) are limited to primary islets from patients and the Sur1 -/- mouse model. Zebrafish exhibit potential as a novel KATP HI model since they express canonical insulin secretion pathway genes and those with identified causative HI mutations...
April 4, 2024: BMJ Open Diabetes Research & Care
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